Clinical Chemistry and Laboratory Medicine

ProGRP dynamics as a prognostic predictor in advanced medullary thyroid carcinomaAlfredo Campennion June 24, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jun 25. doi: 10.1515/cclm-2026-0757. Online ahead of print. ABSTRACT OBJECTIVES: Advanced medullary thyroid carcinoma (MTC) is commonly monitored using calcitonin (CT) and carcinoembryonic antigen (CEA) kinetics. Pro-gastrin-releasing peptide (ProGRP) and carbohydrate antigen 19-9 (CA 19.9) have emerged as potential complementary markers, but their longitudinal prognostic value remains unclear. METHODS: This … Read more

An improved approach to modelling patient reclassification: HbA1c as an exampleChristopher-John Lancaster Farrellon June 23, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jun 24. doi: 10.1515/cclm-2026-0259. Online ahead of print. ABSTRACT BACKGROUND: External quality assurance (EQA) programs must assess whether the analytical performance of commonly used in vitro diagnostic (IVD) devices is fit for their intended clinical use. We developed a method for this assessment based on reclassification of results at clinical … Read more

Unwarranted variation in total B12 test thresholds for the diagnosis of vitamin B12 deficiency across the UK and the validation of a method-specific total B12 reference interval for the Beckman Coulter DxI platform to support implementation of NICE NG239Emma Stevensonon June 23, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jun 24. doi: 10.1515/cclm-2026-0658. Online ahead of print. ABSTRACT BACKGROUND: Prompt diagnosis and treatment of vitamin B12 deficiency prevents haematological, neurological, psychological and psychiatric disturbances. During November 2024, reference interval data used for the clinical interpretation of total B12 assays was collated from participants of the UK NEQAS for Haematinic … Read more

Long-read Oxford Nanopore sequencing enables rapid, cost-effective, and comprehensive TTR genetic testing for hereditary transthyretin amyloidosisGilles Millaton May 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 20. doi: 10.1515/cclm-2026-0553. Online ahead of print. ABSTRACT OBJECTIVES: Hereditary transthyretin amyloidosis (ATTRv) is a rare autosomal dominant disorder caused by pathogenic variants in the TTR gene, with marked clinical heterogeneity and frequent underdiagnosis. Genetic confirmation is essential for patient management but is traditionally based on Sanger sequencing or … Read more

Quantitative analysis and clinical evaluation of 20- and 22-kDa growth hormone isoforms in somatotroph adenoma using immunocapture coupled with LC-MS/MSYao Huon May 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 19. doi: 10.1515/cclm-2026-0382. Online ahead of print. ABSTRACT OBJECTIVES: The 20- and 22-kDa isoforms of growth hormone 1 (GH1) play potentially distinct physiological and pathological roles, but their structural similarity makes quantification challenging. Conventional immunoassays lack sufficient specificity, highlighting the need for more precise analytical methods. METHODS: We developed … Read more

EurA1c: a review of 9 years performance of up to 5120 laboratories in 29 country and 26 manufacturer groups according to current and proposed criteria of the IFCC Model for Quality Targets in relation to the use of HbA1c for monitoring and diagnosis of diabetesEurA1c Trial Groupon May 18, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 May 19. doi: 10.1515/cclm-2026-0276. Online ahead of print. ABSTRACT OBJECTIVES: A major objective of the IFCC Committee for Education in the Use of Biomarkers in Diabetes is to monitor the success of global standardization of HbA1c through benchmark evaluation of the performance by country and manufacturer. METHODS: From 2016 to … Read more

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