Addressing the silent epidemic of recreational nitrous oxide use: a position, call to action and recommendations by the European Federation of Clinical Chemistry and Laboratory Medicine Committee on Biological Markers of Nitrous Oxide AbuseGuillaume Grzychon November 26, 2025 at 11:00 am

Clin Chem Lab Med. 2025 Nov 20. doi: 10.1515/cclm-2025-1060. Online ahead of print. ABSTRACT Recreational nitrous oxide (N2O) use has emerged as a growing public health concern, with increasing reports of neurological, psychiatric, and thrombotic complications. This position paper from the EFLM Committee on Biological Markers of Nitrous Oxide Abuse highlights the urgent need for … Read more

Performance evaluation of a new high-sensitivity cardiac troponin T assay: hs-cTnT (CLIA) assayXin Shuon November 25, 2025 at 11:00 am

Clin Chem Lab Med. 2025 Nov 26. doi: 10.1515/cclm-2025-1258. Online ahead of print. ABSTRACT OBJECTIVES: The Fourth Universal Definition of Myocardial Infarction recommends high-sensitivity cardiac troponin (hs-cTn) as the preferred biomarker for diagnosing myocardial infarction. This study evaluated the analytical and clinical performance of a novel hs-cTnT chemiluminescence immunoassay (CLIA) developed by Mindray. METHODS: Analytical … Read more

Implementation of an automated alert system of critical results in hospitalized and emergency patientsAngela García-de la Torreon November 21, 2025 at 11:00 am

Clin Chem Lab Med. 2025 Nov 24. doi: 10.1515/cclm-2025-1312. Online ahead of print. ABSTRACT OBJECTIVES: The accurate and timely identification and notification of critical results (CR) are crucial to ensure patient safety and is an integral part of the process of medical validation of laboratory results. The objective of the study was to evaluate whether … Read more

Recommendations from the IFCC Working Group on Laboratory Errors and Patient Safety for the Global Adoption of an Essential Quality Indicators Panel in Laboratory MedicineVincent De Guireon November 19, 2025 at 11:00 am

Clin Chem Lab Med. 2025 Nov 20. doi: 10.1515/cclm-2025-1462. Online ahead of print. ABSTRACT OBJECTIVES: To maximize participation in the international standardization effort, this recommendation aims to update the international guidance of the Working Group on Laboratory Errors and Patient Safety of the International Federation of Clinical Chemistry and Laboratory Medicine by identifying a limited … Read more

Uracil in plasma: comparison of two in-house-developed LC-MS/MS methodsSvend H Hansenon November 15, 2025 at 11:00 am

Clin Chem Lab Med. 2025 Nov 17. doi: 10.1515/cclm-2025-0782. Online ahead of print. ABSTRACT OBJECTIVES: To prevent intoxication with 5-fluorouracil (5-FU) during chemotherapy, the initial measurement of plasma uracil levels has recently been recommended by the European Medicines Agency. Here we present and compare two new chromatographic methods for analysis of uracil in plasma. Two … Read more

Capillary blood in core laboratories: current and future challengesÁlvaro Gonzálezon November 13, 2025 at 11:00 am

Clin Chem Lab Med. 2025 Nov 14. doi: 10.1515/cclm-2025-0888. Online ahead of print. ABSTRACT Capillary blood sampling is gaining recognition as a patient-centered alternative to traditional venipuncture. Its main advantages are that it is less invasive, reduces patient discomfort, and potentially can be performed without the direct supervision of a healthcare professional. These features could … Read more

Clinical validation of a DBS-based LC-MS/MS method for 25-hydroxyvitamin D: from lab sampling to home samplingLiesl Heughebaerton November 12, 2025 at 11:00 am

Clin Chem Lab Med. 2025 Nov 13. doi: 10.1515/cclm-2025-1002. Online ahead of print. ABSTRACT OBJECTIVES: As (a lack of) vitamin D has been linked to a wide variety of chronic diseases, there is growing interest in generating robust epidemiological data. Consequently, the need for large-scale biological sample collection has increased. In this context, dried blood … Read more

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