Toxicology and TDMon May 2, 2025 at 10:00 am
Clin Chem Lab Med. 2025 May 2;63(s1):s2643-s2727. doi: 10.1515/cclm-2025-8071. Print 2025 May 26. NO ABSTRACT PMID:40314542 | DOI:10.1515/cclm-2025-8071
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PLENARY LECTURE 4 – Digital Twins: from Personalised Medicine to Precision Public Healthon May 2, 2025 at 10:00 am
Clin Chem Lab Med. 2025 May 2;63(s1):s11. doi: 10.1515/cclm-2025-8008. Print 2025 May 26. NO ABSTRACT PMID:40314541 | DOI:10.1515/cclm-2025-8008
The Departments of Laboratory Medicine and Pathology now rank sixth in total NIH funding in the nation for our discipline.on May 2, 2025 at 4:00 am
The Departments of Laboratory Medicine and Pathology now rank sixth in total NIH funding in the nation for our discipline. The work of our faculty and trainees covers the full spectrum of research with particular strength in immunology, cancer biology, infectious diseases, computational health care, genomics, stem cell biology, neurosciences, diagnostics, and translational research. Yale … Read more
Quality Control Measurements Yield Similar Variation Below and Above Limit of Quantification for High-Sensitivity Cardiac Troponin I Assays
Clin Chem. 2025 May 2:hvaf057. doi: 10.1093/clinchem/hvaf057. Online ahead of print. NO ABSTRACT PMID:40314142 | DOI:10.1093/clinchem/hvaf057
Comprehensive assessment of medical laboratory performance: a 4D model of quality, economics, velocity, and productivity indicatorsPavel S Zubanovon May 2, 2025 at 10:00 am
Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0323. Online ahead of print. ABSTRACT Laboratory diagnostics play a crucial role in modern medicine and healthcare economics. The effective management of a medical laboratory is based on reliable assessment of indicators characterizing quality of testing, productivity, velocity (speed) and cost-effectiveness. The usual concepts of laboratory management … Read more
Pre-analytical phase errors constitute the vast majority of errors in clinical laboratory testingYanchun Linon May 1, 2025 at 10:00 am
Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0190. Online ahead of print. ABSTRACT OBJECTIVES: Clinical laboratory errors pose a threat to patient safety and previous studies have demonstrated that pre-analytical error is the most common error type. Our study aimed to determine the types and frequency of errors occurring in clinical laboratory testing in … Read more
Promising protein biomarkers for early gastric cancer: clinical performance of combined detectionWeifeng Shenon April 30, 2025 at 10:00 am
Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2024-1510. Online ahead of print. ABSTRACT OBJECTIVES: In the early stage of gastric cancer (GC), identifying cancer-specific biomarkers is a key step in the disease screening process. This study aims to explore the clinical value of five novel protein biomarkers and their combination (5 MP) for GC … Read more
Beyond the Hydrashift assay: the utility of isoelectric focusing for therapeutic antibody and paraprotein detectionRieke Reiteron April 30, 2025 at 10:00 am
Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2025-0352. Online ahead of print. ABSTRACT OBJECTIVES: In serum immunofixation electrophoresis, therapeutic monoclonal antibodies (tmAbs) can be misinterpreted as paraproteins. Strategies to circumvent these interferences include the use of anti-tmAb antibodies, which led to the development of the Hydrashift assay. However, this assay is exclusively available for … Read more
Standardization challenges in antipsychotic drug monitoring: insights from a national survey in Chinese TDM practicesWeiyan Zhouon April 30, 2025 at 10:00 am
Clin Chem Lab Med. 2025 May 1. doi: 10.1515/cclm-2025-0186. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) is critical for optimizing antipsychotic therapy, yet inter-laboratory comparability in China remains poor. Unstandardized practices risk suboptimal dosing and adverse effects, highlighting the need for standardization. This study evaluated TDM practices for six antipsychotics (olanzapine, clozapine, … Read more
Performance of the Binding Site cerebrospinal fluid kappa free light chains assaySimon Alfred Handley, Suzanne Barnes, Nicole Jenkins, Troy Wanandy1Biochemistry, Department of Pathology, 34379Royal Hobart Hospital, Hobart, TAS, Australia2College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia3Department of Special Chemistry, Pathwest QE II MC, Nedlands, WA, Australia4Clinical Biochemistry, Alfred Pathology Service, Melbourne, VIC, Australia5Department of Clinical Immunology and Allergy, 34379Royal Hobart Hospital, Hobart, TAS, Australiaon April 12, 2025 at 2:47 am
Annals of Clinical Biochemistry, Ahead of Print. BackgroundMeasurement of cerebrospinal fluid (CSF) kappa free light chains (KFLCs) for the detection of intrathecal immunoglobulin synthesis has generated interest as an alternative to CSF oligoclonal bands due to its rapid turnaround time and ability to …