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Evaluation of measurement uncertainty in direct and estimated serum osmolality according to ISO/TS 20914: implications for clinical diagnostics​Mehmet Fatih Alpdemir Sezen Tutar Medine Alpdemir a Medical Biochemistry, Ministry of Health Ankara Bilkent City Hospital, Ankara, Turkeyb Medical Biochemistry, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkeyon April 4, 2025 at 4:29 am

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Volume 85, Issue 3, MAY 2025, Page 184-189.

Cold activation in PT-INR samples – Myth or reality in the modern laboratory?​Annika Petersson Karin Strandberg Magnus Magnusson Jenny Lerman Kim Ekblom a Department of Clinical Chemistry and Transfusion Medicine, Växjö Central Hospital, Växjö, Swedenb Department of Translational Medicine, Lund University, Lund, Swedenc Department of Clinical Chemistry and Pharmacology, Division of Laboratory Medicine, Coagulation Laboratory, University and Regional Laboratories Region Skåne, Malmö, Swedend Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Swedene Department of Research and Development, Region Kronoberg, Växjö, Swedenon April 4, 2025 at 12:51 pm

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Volume 85, Issue 3, MAY 2025, Page 175-179.

The effects of storage conditions on the stability of salivary melatonin in synthetic fiber swabs for home sampling​Jennifer Anton Charlotte S. Larsen Majken Gudmundsson Lasse K. Bak a Department of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Denmarkb Translational Research Center (TRACE), Copenhagen University Hospital, Rigshospitalet, Denmarkc Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmarkon April 10, 2025 at 2:38 am

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Volume 85, Issue 3, MAY 2025, Page 180-183.

Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA for Identification of Targetable and Resistance Alterations in Advanced Solid Tumors

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Clin Chem. 2025 May 5:hvaf045. doi: 10.1093/clinchem/hvaf045. Online ahead of print. ABSTRACT BACKGROUND: Existing circulating cell-free DNA (cfDNA) assays are primarily centralized, requiring specialized sample handling and transportation. Implementing a flexible, decentralized sequencing system at point of care, with minimal technical oversight, can enhance turnaround times and patient access to genomic profiling. In this study, … Read more

Detecting cardiac injury: the next generation of high-sensitivity cardiac troponins improving diagnostic outcomesGiuseppe Lippion May 4, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0418. Online ahead of print. ABSTRACT Cardiac injury, encompassing a spectrum of heart muscle damage, requires prompt and accurate diagnosis to improve patient outcomes. Early detection using cardiac biomarkers is vital for timely intervention and reducing mortality. This review highlights the role of high-sensitivity cardiac troponins (hs-cTns) … Read more

A value-based score for clinical laboratories: promoting the work of the new EFLM committeeMario Plebanion May 2, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 5. doi: 10.1515/cclm-2025-0490. Online ahead of print. ABSTRACT After the dissemination of a manifesto for the implementation of value-based laboratory medicine (VBLM) and a Strategic Conference dedicated to this issue, a novel initiative of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) is to be initiated with … Read more

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