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A New International Patient-Based External Quality Assessment Program to Monitor Harmonization and Standardization Efforts

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Clin Chem. 2025 Oct 10:hvaf122. doi: 10.1093/clinchem/hvaf122. Online ahead of print. ABSTRACT BACKGROUND: External quality assessment (EQA) should strive to monitor and reflect variation across laboratories and measuring systems. We introduce a newly developed patient-based EQA program named Noklus Patient Median (NOPAM) that is freely available for the participants. The results from NOPAM enable laboratories … Read more

Quantitative Analysis of a Novel Metabolite Panel to Estimate GFR (Panel eGFR) in Serum and Plasma Using LC-MS/MS

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Clin Chem. 2025 Oct 10:hvaf110. doi: 10.1093/clinchem/hvaf110. Online ahead of print. ABSTRACT BACKGROUND: Estimated glomerular filtration rate (eGFR) using creatinine (eGFRcr), cystatin C (eGFRcys), or both (eGFRcr-cys) is not sufficiently accurate in many settings, often due to non-glomerular filtration rate (GFR) determinants of the filtration markers. In principle, using a panel of endogenous markers (panel … Read more

Performance of GFAP and UCH-L1 compared to S100B in detecting intracranial injury: influence of age, hemolysis, neurodegenerative diseases, and extracranial fractures in a prospective cohort of over 1,000 patientsAntoine Puraveton October 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 9. doi: 10.1515/cclm-2025-1129. Online ahead of print. ABSTRACT OBJECTIVES: To compare the diagnostic performances of GFAP and UCH-L1 with S100B in detecting intracranial injury, while investigating the impact of confounding factors. METHODS: In a large prospective cohort of 1,010 patients with mild traumatic brain injury, we first evaluated the … Read more

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