Journal

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of mycophenolic acid glucuronide in human serum and plasmaTobias Schierscheron November 7, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-1052. Online ahead of print. ABSTRACT OBJECTIVES: A candidate reference measurement procedure (RMP) based on isotope dilution (ID) liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated to accurately measure serum and plasma concentrations of mycophenolic acid glucuronide (MPAG). METHODS: Quantitative nuclear magnetic resonance (qNMR) spectroscopy was … Read more

Pro-gastrin releasing peptide as a tumor marker of medullary thyroid carcinoma: a comparative bivariate meta-analysisPetra Petranović Ovčaričekon November 7, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-0867. Online ahead of print. ABSTRACT OBJECTIVES: Calcitonin (CT) is the established biomarker for medullary thyroid carcinoma (MTC), but its measurement is hampered by analytical limitations. Procalcitonin (PCT) and pro-gastrin-releasing peptide (ProGRP) have been proposed as alternative or complementary markers, yet the diagnostic value of ProGRP remains … Read more

Reimagining External Quality Assessment for precision medicine: a perspective from biochemistry laboratoriesStanford Chigaroon November 7, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-1240. Online ahead of print. ABSTRACT External Quality Assessment (EQA) is central to quality assurance in laboratory medicine, providing independent measures of tests trueness, and inter-laboratory comparability. Traditional EQA schemes, designed around stable and well-characterised measurands, have been successful in routine analytes such as electrolytes and liver … Read more

Single Nucleotide Polymorphism Typing Going Spatial: In Situ Padlock Probes Targeting mRNA Variants to Identify Haploidentical Cells within the Tissue Environment

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Clin Chem. 2025 Nov 4:hvaf119. doi: 10.1093/clinchem/hvaf119. Online ahead of print. ABSTRACT BACKGROUND: Despite almost 3 decades of research, the mechanisms underlying the bidirectional trafficking of cells at the maternal-fetal interface that gives rise to microchimerism remain poorly understood. A major barrier to progress has been the lack of suitable detection methods capable of distinguishing … Read more

Spot urine is a suitable matrix for measurement of copeptinJulie Sherfanon November 4, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 5. doi: 10.1515/cclm-2025-1055. Online ahead of print. ABSTRACT OBJECTIVES: To validate urine as a suitable matrix for copeptin measurements, derive a urinary copeptin/creatinine ratio in an apparently healthy sample of the population, and assess pre-analytical conditions such as collection type and storage temperatures that affect stability and recovery. METHODS: … Read more

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