Dental amalgams and blood mercury concentrations in American adultsDavid A Geieron October 19, 2025 at 10:00 am

Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-0909. Online ahead of print. ABSTRACT OBJECTIVES: Dental amalgam (50 % mercury (Hg) by weight) is a commonly used material to restore a tooth damaged by decay. In recent years, amalgam safety has become a matter of ongoing controversy. This hypothesis-testing epidemiological study evaluated the relationship between … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of cortisol in human urineMyriam Otton October 19, 2025 at 10:00 am

Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-0522. Online ahead of print. ABSTRACT OBJECTIVES: Precise and accurate determination of urinary cortisol is important for diagnosis and monitoring of cortisol excess and deficiency. To achieve this, a selective and specific, isotope-dilution two-dimensional heart-cut liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based method was developed. METHODS: A novel, two-dimensional … Read more

Optimization and comparison of genomic DNA extraction from whole blood collected in PAXgene blood RNA tube using automated platformsJianlan Youon October 19, 2025 at 10:00 am

Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2025-1079. Online ahead of print. ABSTRACT OBJECTIVES: With the development of genomic technologies, the isolation of genomic DNA (gDNA) from clinical samples has become more important for both clinical diagnostics and research studies. Blood samples collected in PAXgene Blood RNA Tubes, which are typically used for RNA … Read more

An isotope dilution-liquid-chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of mycophenolic acid in human serum and plasmaTobias Schierscheron October 17, 2025 at 10:00 am

Clin Chem Lab Med. 2025 Oct 20. doi: 10.1515/cclm-2024-0860. Online ahead of print. ABSTRACT OBJECTIVES: A candidate reference measurement procedure (RMP) based on isotope dilution (ID) liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated to accurately measure serum and plasma concentrations of mycophenolic acid (MPA). METHODS: Quantitative nuclear magnetic resonance (qNMR) spectroscopy was utilized … Read more

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