Publication date: 1 April 2026 Source: Clinica Chimica Acta, Volume 585 Author(s): Obaid Afzal, Ali Altharawi, Mubarak A. Alamri, Manal A. Alossaimi, Abdulmalik S.A. Altamimi, Pawan Goud, Prerna Uniyal, Rakhi Mishra
Publication date: March 2026 Source: Clinical Biochemistry, Volume 142 Author(s): Victoria Higgins, Michelle L. Parker, Basma Ahmed, Vipin Bhayana, Ronald A. Booth, Yu Chen, Christine Collier, Mark S. Freedman, Myriam Gagné, Ola Z. Ismail, Jessica L. Gifford, Joseph Macri, Craig S. Moore, Ashley Newbigging, Lily Olayinka, Ilia Poliakov, Karina Rodriguez-Capote, Raphael Schneider, Simon Thebault, Liju … Read more
Clin Chem Lab Med. 2026 Feb 17. doi: 10.1515/cclm-2025-1670. Online ahead of print. ABSTRACT OBJECTIVES: Screening for primary aldosteronism (PA) using the aldosterone:renin ratio (ARR) has suboptimal diagnostic accuracy, particularly in females. We assessed whether accuracy could be improved using sex-specific relationships of aldosterone with renin. METHODS: Plasma aldosterone and renin were measured in 442 … Read more
Clin Chem. 2026 Feb 16:hvag004. doi: 10.1093/clinchem/hvag004. Online ahead of print. ABSTRACT BACKGROUND: Biallelic loss-of-function variants of STRC are a frequent cause of mild to moderate nonsyndromic hearing loss. The high (>98%) sequence homology between STRC and its pseudogene STRCP1 poses a significant challenge for accurate interpretation of STRC variants using standard methods. Although STRC-STRCP1 … Read more
Clin Chem Lab Med. 2026 Feb 12. doi: 10.1515/cclm-2025-1138. Online ahead of print. ABSTRACT OBJECTIVES: The clinical utility of serum bone turnover markers (BTMs) in managing osteoporosis in the elderly is constrained by the absence of personalized reference intervals (prRI) based on biological variation (BV). METHODS: This longitudinal study tracked monthly serum levels of β-CTX, … Read more
Clin Chem Lab Med. 2026 Feb 13. doi: 10.1515/cclm-2025-1722. Online ahead of print. ABSTRACT OBJECTIVES: Identifying individuals with vitamin B12 (B12) deficiency is challenging due to poor harmonization across total B12 assays. To establish clinically meaningful thresholds for the Roche assay, we characterized B12 concentrations associated with deficiency by comparing individuals with macrocytic anemia and … Read more
Clin Chem Lab Med. 2026 Feb 17. doi: 10.1515/cclm-2026-0115. Online ahead of print. ABSTRACT OBJECTIVES: The acute coronary syndrome (ACS) is a leading cause of morbidity and mortality worldwide, with timely diagnosis being critical for improving outcomes. Since high-sensitivity cardiac troponin (hs-cTn) assays have become the gold standard for detecting myocardial injury, this study aimed … Read more
Clin Chem Lab Med. 2026 Feb 12. doi: 10.1515/cclm-2026-0152. Online ahead of print. NO ABSTRACT PMID:41696972 | DOI:10.1515/cclm-2026-0152
Clin Chem Lab Med. 2026 Feb 16. doi: 10.1515/cclm-2026-0149. Online ahead of print. ABSTRACT Lipoprotein(a) (Lp(a)) has the reputation of being the most misunderstood metric in laboratory medicine. The unique apolipoprotein(a) (apo(a)) in Lp(a) is very heterogenous, the kringle IV domain of apo(a) being formed by 12-50 kringles due to 3 to ∼40 KIV2 repeats. … Read more
Clin Chem Lab Med. 2026 Feb 17. doi: 10.1515/cclm-2025-1529. Online ahead of print. NO ABSTRACT PMID:41696968 | DOI:10.1515/cclm-2025-1529
