Journal

Validation study of the Helena V8 UltraCE capillary elecrophoresis analyserJoris R Delangheon January 2, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 5. doi: 10.1515/cclm-2025-1523. Online ahead of print. ABSTRACT OBJECTIVES: Serum protein electrophoresis is one of the keystone investigations for screening for monoclonal proteins and assessing the serum protein profile. The newly released Helena V8ultra capillary electrophoresis system has been evaluated. METHODS: In total, 164 serum samples were assessed on … Read more

Laboratory findings in patients treated with complement factor C3 inhibitor pegcetacoplanSaskia M C Langemeijeron January 2, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 5. doi: 10.1515/cclm-2025-1270. Online ahead of print. ABSTRACT OBJECTIVES: Complement inhibitor pegcetacoplan binds to C3 and its activation product C3b. Pegcetacoplan has been approved for the treatment of paroxysmal nocturnal hemoglobinuria. Because pegcetacoplan exerts broad inhibition of the complement cascade its efficacy is also investigated in numerous other diseases … Read more

At-home blood collection for clinical chemistry analyses in a kidney transplant population: a feasibility studyJorrit Hoekstraon January 2, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 5. doi: 10.1515/cclm-2025-1199. Online ahead of print. ABSTRACT OBJECTIVES: To investigate the feasibility of at-home collection of liquid capillary blood samples for clinical chemistry analyses. METHODS: Kidney transplant recipients performed a fingerprick to collect capillary blood samples. Samples were kept at room temperature for 24 h before further processing. … Read more

Analytical and diagnostic evaluation of the Anvajo fluidlab 2 analyzer: a novel urine particle analyzer for clinical application using digital holographic microscopy?Sigrid Deprezon January 2, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 2. doi: 10.1515/cclm-2025-1202. Online ahead of print. ABSTRACT OBJECTIVES: The performance of a novel urine particle analyzer, fluidlab 2 (Anvajo GmbH, Dresden, Germany), was evaluated against phase-contrast visual microscopy according to the most recent EFLM European Urinalysis Guideline. METHODS: The fluidlab 2 device combines digital holographic microscopy with neural … Read more

Uterus Transplantation-Current Evaluation, Monitoring, and Emerging Diagnostics

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Clin Chem. 2025 Dec 30;72(1):18-26. doi: 10.1093/clinchem/hvaf143. ABSTRACT BACKGROUND: Uterus transplantation (UTx) is uniquely positioned at the transition from experimental to clinical reality for women with absolute uterine factor insufficiency. As the technique gains wider clinical adoption, there is a growing need for standardization in both protocols and diagnostics. CONTENT: This review describes the current … Read more

The Mutational Epidemiology of Childhood Cancer

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Clin Chem. 2025 Dec 30;72(1):140-151. doi: 10.1093/clinchem/hvaf154. ABSTRACT BACKGROUND: Childhood cancers comprise a variety of liquid and solid tumors that display different patterns of incidence than adult cancers. Most have distinct molecular subtypes characterized by specific genomic driver events. The mutational processes that influence the somatic landscape of cancers also generate distinctive mutational signatures (mutSig). … Read more

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