Journal

Establishing reference intervals for venous whole blood micronutrients in the healthy older Chinese population via dried blood spot technology​on October 23, 2025 at 12:19 pm

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Publication date: 15 January 2026 Source: Clinica Chimica Acta, Volume 579 Author(s): Zehao Wang, Huilian Duan, Xiaocui Cheng, Cheng Cheng, Wen Li, Fei Ma, Ruikun He, Zhongxia Li, Mengtong Yang, Di Wang, Zhenghua Huang, Yongjie Chen, Guowei Huang  

Hemolysis index. Can we uncritically trust manufacturer declarations?Alen Vrtaricon October 23, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 23. doi: 10.1515/cclm-2025-1302. Online ahead of print. ABSTRACT OBJECTIVES: Hemolysis is a common preanalytical interference in clinical biochemistry, affecting up to 3.3 % of routine samples and contributing to approximately 60 % of rejected specimens. It results from the release of intracellular constituents, such as hemoglobin and potassium, into … Read more

ReferenceRangeR: a novel tool designed to facilitate reference interval estimation and verificationGunnar Brandhorston October 22, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 23. doi: 10.1515/cclm-2025-0637. Online ahead of print. ABSTRACT OBJECTIVES: Reference intervals (RIs) are essential for interpreting laboratory test results. It is recommended that each medical laboratory establishes and reviews its own RIs. The use of direct methods is often unfeasible for most laboratories, while indirect methods are a more … Read more

Use of indirect methods and machine learning algorithms for the estimation of reference intervals, taking cortisol measurements as an exampleFatma Demet Arslanon October 21, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Oct 23. doi: 10.1515/cclm-2025-0984. Online ahead of print. ABSTRACT OBJECTIVES: This study aims to determine reliable reference intervals (RIs) for total cortisol (TC) in adults considering the effects of both age and blood collection time, using indirect methods and machine learning approaches. METHODS: Serum TC results from blood samples collected … Read more

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