Journal

Clin Chem. 2026 Jan 29:hvaf190. doi: 10.1093/clinchem/hvaf190. Online ahead of print. ABSTRACT BACKGROUND: Primary immunodeficiencies (PIDs) are rare disorders caused by immune system defects that are commonly screened using multi-parameter flow cytometry (FCM). To counter the subjective and time-consuming manual data analysis of FCM data, we present PIDgeon, a fully automated computational pipeline based on … Read more

Clin Chem. 2026 Jan 28:hvaf187. doi: 10.1093/clinchem/hvaf187. Online ahead of print. ABSTRACT BACKGROUND: While most pulmonary infections with Coccidioides spp. are self-limited, a subset of patients is at higher risk for severe disease and extrapulmonary dissemination, including individuals with certain ethnic backgrounds. Disseminated disease can involve soft tissues, bones, and the central nervous system with … Read more

Clin Chem. 2026 Jan 28:hvaf168. doi: 10.1093/clinchem/hvaf168. Online ahead of print. ABSTRACT BACKGROUND: Diagnosis and risk stratification of acute heart failure (HF) in the emergency department (ED) remains challenging. N-terminal pro-B type natriuretic peptide (NT-proBNP) measurement is useful in evaluating acute dyspnea. The objective of this study was to evaluate the diagnostic performance of a … Read more

Clin Chem. 2026 Jan 28:hvaf176. doi: 10.1093/clinchem/hvaf176. Online ahead of print. ABSTRACT BACKGROUND: Real-time reverse transcription quantitative PCR (RT-qPCR) is utilized in many areas of the life sciences, diagnostics, and forensics, yet concerns about methodological quality and reporting transparency persist. Diagnostic testing during the recent pandemic brought those concerns into the public domain. The Minimum … Read more