Journal

From conventional to personalized reference intervals and decision limits: addressing latent errors in the post-post analytical phaseAbdurrahman Coskunon November 27, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 28. doi: 10.1515/cclm-2025-1338. Online ahead of print. ABSTRACT Laboratory errors are an important component of medical errors and are predominantly associated with the extra-analytical phases of the total testing process, particularly the pre-pre-analytical and post-post-analytical phases, which are largely dependent on clinical activities but also require laboratory support. The … Read more

Addressing the silent epidemic of recreational nitrous oxide use: a position, call to action and recommendations by the European Federation of Clinical Chemistry and Laboratory Medicine Committee on Biological Markers of Nitrous Oxide AbuseGuillaume Grzychon November 26, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 20. doi: 10.1515/cclm-2025-1060. Online ahead of print. ABSTRACT Recreational nitrous oxide (N2O) use has emerged as a growing public health concern, with increasing reports of neurological, psychiatric, and thrombotic complications. This position paper from the EFLM Committee on Biological Markers of Nitrous Oxide Abuse highlights the urgent need for … Read more

Performance evaluation of a new high-sensitivity cardiac troponin T assay: hs-cTnT (CLIA) assayXin Shuon November 25, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 26. doi: 10.1515/cclm-2025-1258. Online ahead of print. ABSTRACT OBJECTIVES: The Fourth Universal Definition of Myocardial Infarction recommends high-sensitivity cardiac troponin (hs-cTn) as the preferred biomarker for diagnosing myocardial infarction. This study evaluated the analytical and clinical performance of a novel hs-cTnT chemiluminescence immunoassay (CLIA) developed by Mindray. METHODS: Analytical … Read more

Analytical Imprecision and Therapeutic Intervals for Lithium – Are There Implications for Old Age Patients with Bipolar Disorder?​​on November 25, 2025 at 4:00 pm

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Publication date: January 2026 Source: Clinical Biochemistry, Volume 141 Author(s): Janet Zhou, Demitra Tsoukalas, Nethra Chittiprol, Peter Kavsak, Felix Leung, Jennifer Taher, Zahraa Ali-Mohammed, Saranya Arnoldo, Heather Tysick, Lei Fu, Sara A. Love, Rajeevan Selvaratnam

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