Journal

Unity among the units – a position paper by the DGKLRalf Junkeron March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 18. doi: 10.1515/cclm-2026-0075. Online ahead of print. ABSTRACT More than 30 years after German reunification, the units of measurement used for laboratory medical parameters still differ between eastern and western Germany. While the eastern German states predominantly use “SI” units, “conventional” units are common in medical facilities in the … Read more

Biological variation outweighs pre-analytical factors in coagulation reference intervals: a multicenter big data study​on March 19, 2026 at 1:36 pm

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Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Fabio Del Ben, Gabriella Azzarini, Alessandra Brocca, Paola Centa, Maria Rita Cozzi, Claudio De Seta, Arianna Fassina, Elisabetta Fontanini, Roberta Giacomello, Giovanni Poli, Paola Pradella, Liliana Santarossa, Lorena Zardo, Benedetto Morelli  

The label-free electrochemical S100B-TBI immunosensor for sensitive detection of S100B protein as a biomarker for traumatic brain injury using FFT-SWV voltammetry​on March 19, 2026 at 1:36 pm

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Publication date: 1 June 2026 Source: Clinica Chimica Acta, Volume 588 Author(s): Mehrasa Rahimi Borumand, Mojtaba Mojtahedzadeh, Shokoufeh Hassani, Mazda Rad-Malekshahi, Hashem Kazemzadeh-Beneh, Parisa Kianpour, Fatemeh Babaloii, Marziye Karimzade, Amirmahdi Mojtahedzadeh, Parviz Norouzi, Hamid Akbari Javar  

Serum protein electrophoresis pattern associated with elevated polyclonal IgG4 concentrations: a monoclonal-mimicking profile with potentially significant clinical implicationsLaura Michettion March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0183. Online ahead of print. ABSTRACT OBJECTIVES: To estimate the frequency and characterize the distinctive features of the serum electrophoretic pattern associated with polyclonal elevations of IgG4, and to evaluate its clinical relevance. METHODS: A total of 127,827 serum protein electrophoresis (SPEP) analyses performed in our laboratory … Read more

Representation and performance of CE-marked and in-house in vitro diagnostic tests for routine laboratory parameters in external quality assessment programmesChristoph Buchtaon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 17. doi: 10.1515/cclm-2026-0288. Online ahead of print. ABSTRACT OBJECTIVES: European legislation requires detailed performance evaluation of in vitro diagnostic medical devices (IVD-MD) by both commercial manufacturers (through the Conformité Européenne (CE) mark) and in-house (IH) IVDs. Little information is currently available on how CE- and IH-IVDs are mapped in … Read more

Current practices and harmonization challenges in Alzheimer’s disease biomarkers: an EFLM Committee: Harmonization SurveyLuisa Agnelloon March 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 16. doi: 10.1515/cclm-2026-0168. Online ahead of print. ABSTRACT OBJECTIVES: Fluid biomarkers are central to the biological definition and diagnosis of Alzheimer’s disease (AD). Despite international recommendations, substantial variability persists in laboratory practices. This survey, promoted by the Committee: Harmonisation (C:H) of the European Federation of Clinical Chemistry and Laboratory … Read more

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