Journal

Evaluation of a New Antibody-Based NT-proBNP Assay for Acute Dyspnea in the Emergency Department

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Clin Chem. 2026 Jan 28:hvaf168. doi: 10.1093/clinchem/hvaf168. Online ahead of print. ABSTRACT BACKGROUND: Diagnosis and risk stratification of acute heart failure (HF) in the emergency department (ED) remains challenging. N-terminal pro-B type natriuretic peptide (NT-proBNP) measurement is useful in evaluating acute dyspnea. The objective of this study was to evaluate the diagnostic performance of a … Read more

Real-Time Reverse Transcription Quantitative PCR (RT-qPCR) Methodological Standards and Reporting Practices

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Clin Chem. 2026 Jan 28:hvaf176. doi: 10.1093/clinchem/hvaf176. Online ahead of print. ABSTRACT BACKGROUND: Real-time reverse transcription quantitative PCR (RT-qPCR) is utilized in many areas of the life sciences, diagnostics, and forensics, yet concerns about methodological quality and reporting transparency persist. Diagnostic testing during the recent pandemic brought those concerns into the public domain. The Minimum … Read more

The oxalobiome: unraveling the role of gut microbiota in oxalate metabolism and its implications for kidney health and disease management​on January 28, 2026 at 3:37 pm

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Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): David Mburu, Sumeet Kumar, Yanzhe Wang, Asadoor Amirkhani Namagerdi, Karoona Bai, Bilal Ali, Ahmed Minalla, Karina Ordaya Gonzales, Khalid A. Abdelhalim  

Effect of storage conditions on NSE, S100, and B2M stability in cerebrospinal fluid and serumNatalia García-Sanchaon January 27, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 28. doi: 10.1515/cclm-2025-1320. Online ahead of print. ABSTRACT OBJECTIVES: The reliability of cerebrospinal fluid (CSF) and serum biomarkers depends on sample integrity, which is strongly influenced by storage conditions. While -80 °C is considered the gold standard for long-term preservation, it requires specialized infrastructure, whereas -20 °C is more … Read more

Predicting congenital hypothyroidism in newborns with complex risk profiles by using thyroid-stimulating hormone variations across serial dried blood spotsLaura Cappellettion January 27, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 28. doi: 10.1515/cclm-2025-1387. Online ahead of print. ABSTRACT OBJECTIVES: Newborn screening for congenital hypothyroidism (CH) relies on thyroid-stimulating hormone (TSH) levels from dried blood spots (DBS). We investigated whether incorporating TSH variation across serial DBS could improve prediction of CH in term and preterm infants with complex risk profiles. … Read more

Plasma non-targeted metabolomics unveils the metabolic signatures of trans-right ventricle in pulmonary arterial hypertension associated with atrial septal defect​on January 27, 2026 at 2:26 pm

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Publication date: 15 March 2026 Source: Clinica Chimica Acta, Volume 584 Author(s): Xifeng Qian, Yuanrui Deng, Tingting Guo, Xin Huang, Chaowu Yan, Xin Gao, Yan Wu, Song Hu, Jiangshan Tan, Lingtao Chong, Shengsong Zhu, Mingjie Ma, Mengting Ye, Xiaojian Wang, Jian Cao, Lu Hua  

Utility of flow cytometric PAX5 protein detection for the diagnosis of B-cell acute lymphoblastic leukemiaTanintorn Pootrakulon January 27, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 28. doi: 10.1515/cclm-2025-1647. Online ahead of print. ABSTRACT OBJECTIVES: Accurate B-lineage assignment in acute leukemia is critical for therapeutic decisions. While nuclear expression of PAX5 protein (nPAX5) is a highly reliable marker for B-cell differentiation, its conventional assessment by time-consuming immunohistochemistry (IHC) is not ideal for rapid diagnosis. This … Read more

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