Journal

DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping

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Clin Chem. 2026 Mar 9:hvag007. doi: 10.1093/clinchem/hvag007. Online ahead of print. ABSTRACT BACKGROUND: DPYD testing can identify patients at risk for severe toxicity when a standard fluoropyrimidine antineoplastic dose is prescribed. Sequencing-based methods detect rare variants, which require classification. METHODS: DPYD sequencing results over a 9-year period through to 2024 were analyzed. The dataset was … Read more

CYFRA 21-1 in lymph node fine-needle aspiration washouts: added value in differentiated thyroid cancerAlfredo Campennion March 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2026-0251. Online ahead of print. ABSTRACT OBJECTIVES: Cervical lymph node metastases represent a key challenge in patients with differentiated thyroid carcinoma (DTC). Fine-needle aspiration cytology (FNAC) and thyroglobulin (Tg) measurement in fine-needle washout (FNA-Tg) are widely used but have recognized limitations. Cytokeratin 19 fragment 21-1 measurement in … Read more

Towards the future of Endocrine Laboratory Medicine: defining the role of laboratory medicine specialists to strengthen the clinical-biological partnership – a joint opinion paper of EFLM-C:YS, IFCC TF-YS, and ESE-EYESCharles R Lefèvreon March 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2026-0101. Online ahead of print. ABSTRACT Clinical endocrinology relies critically on high-quality biochemical data for diagnosis, therapeutic decisions, and long-term patient monitoring. As endocrine diagnostics grow more complex due to expanding test menus, technological advances, and changing patient populations, the need for a strong, structured partnership between … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of 17-hydroxyprogesterone in human serum and plasmaMartina Bachmannon March 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2025-1169. Online ahead of print. ABSTRACT OBJECTIVES: Accurate measurement of 17α-hydroxyprogesterone (17-OHP) in human serum and plasma is required for steroid profiling, to ensure the appropriate diagnosis of congenital adrenal hyperplasia. Therefore, an isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) to quantify 17-OHP … Read more

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