Prospective real-time implementation and verification of patient-based real-time quality control using average of normals in a tertiary hospital laboratorySe-Eun Kooon July 16, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Jul 17. doi: 10.1515/cclm-2026-0201. Online ahead of print. ABSTRACT OBJECTIVES: Practical implementation of patient-based real-time quality control (PBRTQC) requires analyte- and institution-specific optimization. This study evaluated the operational feasibility of average-of-normals (AoN)-based PBRTQC through a structured selection process and prospective event-based validation. METHODS: PBRTQC monitoring was performed using the Average … Read more

Establishment of DBS-based reference intervals for vitamins, essential elements, and potentially toxic elements in Chinese adults from Hubei ProvinceMengtong Yangon July 15, 2026 at 10:00 am

Clin Chem Lab Med. 2026 Jul 16. doi: 10.1515/cclm-2026-0511. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to establish a comprehensive panel of dried blood spot (DBS)-specific reference intervals (RIs) for vitamins, essential elements, and potentially toxic elements (PTEs) in Chinese adults, and to introduce a hierarchical decision framework for selecting between healthy- and … Read more

Characterization of the Migration Profile of 36 Therapeutic Monoclonal Antibodies in Serum Protein Electrophoresis and Immunofixation

Clin Chem. 2026 Jul 15:hvag080. doi: 10.1093/clinchem/hvag080. Online ahead of print. ABSTRACT BACKGROUND: Therapeutic monoclonal antibodies (t-mAbs) are widely used in oncology, hematology, and immune-mediated diseases. Some t-mAbs are detectable by serum protein electrophoresis (SPEP) and immunofixation (IF), potentially mimicking monoclonal gammopathies. Despite widespread use, migration profiles of many t-mAbs remain incompletely described. METHODS: Thirty-six … Read more

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