Editor’s Note: Circulating Proteolytic Products of Carboxypeptidase N for Early Detection of Breast Cancer
Clin Chem. 2026 Jun 22:hvag058. doi: 10.1093/clinchem/hvag058. Online ahead of print. NO ABSTRACT PMID:42329672 | DOI:10.1093/clinchem/hvag058
Journal
In Reply to Reflexing NT-proBNP for sFlt-1/PlGF Ratios That Fall into the Measurement Uncertainty for Preeclampsia Risk Classification
Clin Chem. 2026 Jun 20:hvag071. doi: 10.1093/clinchem/hvag071. Online ahead of print. NO ABSTRACT PMID:42322433 | DOI:10.1093/clinchem/hvag071
Reflexing NT-proBNP for sFlt-1/PlGF Ratios That Fall into the Measurement Uncertainty for Preeclampsia Risk Classification
Clin Chem. 2026 Jun 20:hvag070. doi: 10.1093/clinchem/hvag070. Online ahead of print. NO ABSTRACT PMID:42322408 | DOI:10.1093/clinchem/hvag070
ProGRP dynamics as a prognostic predictor in advanced medullary thyroid carcinomaAlfredo Campennion June 24, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Jun 25. doi: 10.1515/cclm-2026-0757. Online ahead of print. ABSTRACT OBJECTIVES: Advanced medullary thyroid carcinoma (MTC) is commonly monitored using calcitonin (CT) and carcinoembryonic antigen (CEA) kinetics. Pro-gastrin-releasing peptide (ProGRP) and carbohydrate antigen 19-9 (CA 19.9) have emerged as potential complementary markers, but their longitudinal prognostic value remains unclear. METHODS: This … Read more
From microscope to artificial intelligence: potential and perils in bone marrow evaluationSander De Bruyneon June 23, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Jun 25. doi: 10.1515/cclm-2026-0640. Online ahead of print. NO ABSTRACT PMID:42335417 | DOI:10.1515/cclm-2026-0640
Shift happens again: a call to action for EQA providers to rise to the post market surveillance challengeRachel Marringtonon June 23, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Jun 24. doi: 10.1515/cclm-2026-0786. Online ahead of print. NO ABSTRACT PMID:42335313 | DOI:10.1515/cclm-2026-0786
An improved approach to modelling patient reclassification: HbA1c as an exampleChristopher-John Lancaster Farrellon June 23, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Jun 24. doi: 10.1515/cclm-2026-0259. Online ahead of print. ABSTRACT BACKGROUND: External quality assurance (EQA) programs must assess whether the analytical performance of commonly used in vitro diagnostic (IVD) devices is fit for their intended clinical use. We developed a method for this assessment based on reclassification of results at clinical … Read more
Unwarranted variation in total B12 test thresholds for the diagnosis of vitamin B12 deficiency across the UK and the validation of a method-specific total B12 reference interval for the Beckman Coulter DxI platform to support implementation of NICE NG239Emma Stevensonon June 23, 2026 at 10:00 am
Clin Chem Lab Med. 2026 Jun 24. doi: 10.1515/cclm-2026-0658. Online ahead of print. ABSTRACT BACKGROUND: Prompt diagnosis and treatment of vitamin B12 deficiency prevents haematological, neurological, psychological and psychiatric disturbances. During November 2024, reference interval data used for the clinical interpretation of total B12 assays was collated from participants of the UK NEQAS for Haematinic … Read more
TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations
Clin Chem. 2026 Jun 24:hvag075. doi: 10.1093/clinchem/hvag075. Online ahead of print. NO ABSTRACT PMID:42336355 | DOI:10.1093/clinchem/hvag075
Rapid Detection of Hemoglobinopathy Variants Using One-Step Library Preparation and Nanopore Sequencing
Clin Chem. 2026 Jun 23:hvag072. doi: 10.1093/clinchem/hvag072. Online ahead of print. ABSTRACT BACKGROUND: Third-generation sequencing (TGS) enables comprehensive detection of rare hemoglobin (Hb) variants due to its long-read capability. However, library preparation is often labor-intensive and time-consuming. This study developed a novel one-step library preparation (OSLP) method for TGS. By integrating barcode sequences into target-specific … Read more