Journal

Unified definition of integrated diagnostics: a position statement of the EFLMJochen K Lennerzon August 6, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 7. doi: 10.1515/cclm-2026-0949. Online ahead of print. ABSTRACT Integrated diagnostics is an emerging multidisciplinary model of care that integrates traditionally siloed domains, including pathology, radiology, genomics, and laboratory medicine, into a coordinated framework designed to improve diagnostic accuracy, treatment selection, and clinical outcomes. In this position statement, the EFLM … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of meropenem in human serum and plasmaRupert Schmidon August 5, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 6. doi: 10.1515/cclm-2026-0428. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic drug monitoring (TDM) of meropenem is critical for optimizing clinical efficacy and minimizing toxicity. We describe the validation of an isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS) candidate reference measurement procedure (RMP) for the quantification of meropenem in human serum … Read more

Enriching Microbial Cell-Free DNA in Clinical Metagenomics Using Epigenetic Filters

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Clin Chem. 2026 Aug 5:hvag089. doi: 10.1093/clinchem/hvag089. Online ahead of print. ABSTRACT INTRODUCTION: Noninvasive cell-free DNA (cfDNA) metagenomic sequencing enables hypothesis-free detection of microbial pathogens in patients with suspected infections. However, its clinical sensitivity is often limited by the overwhelming background of host-derived cfDNA, which can obscure low-abundance microbial signals. We developed an epigenetically guided … Read more

APOB to Estimated APOB Ratio for Screening for the APOE2 Genotype

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Clin Chem. 2026 Aug 3:hvag094. doi: 10.1093/clinchem/hvag094. Online ahead of print. ABSTRACT BACKGROUND: Familial dysbetalipoproteinemia (FDB) is a genetic lipoprotein disorder that can develop in patients homozygous for the apolipoprotein 2 (APOE2) genotype (APOE ɛ2/ɛ2). It is associated with decreased clearance of remnant lipoproteins and increased atherosclerotic cardiovascular disease (ASCVD) risk disproportionate to low-density lipoprotein-cholesterol … Read more

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