Falsely elevated FSH levels due to assay interference: a case-based approachon August 23, 2025 at 12:02 pm
Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Bünyamin Kanat, Gokce Atikeler, Elif Azarsiz
Journal
Survey on critical results management in Brazilian clinical laboratories: Profiling practices through multivariate analysis and a “New Statistics” approachon August 23, 2025 at 12:02 pm
Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Alan Carvalho Dias, Derliane de Oliveira, Fernando de Almeida Berlitz, José Antônio Tesser Poloni, Wilson Shcolnik, Claudia Maria Meira Dias, Daniane Grando Remor Canalli, Luisane Maria Falci Vieira, Bruna Dolci Andreguetto, Felipe Magalhães Furtado, Rafael Monsores Lopes, Adriano Basques Fernandes, Leonardo de Souza … Read more
A Parametric Empirical Bayes Approach to Personalized Reference Intervals and Reference Change Values
Clin Chem. 2025 Aug 22:hvaf092. doi: 10.1093/clinchem/hvaf092. Online ahead of print. ABSTRACT BACKGROUND: Population-wide reference intervals (RIpop) are commonly used in laboratory medicine but may not reflect an individual’s tightly regulated homeostatic interval. Personalized reference intervals (RIper) could enhance diagnostic precision by accounting for individual variability. A parametric empirical Bayes (PEB) framework stabilizes individual estimates … Read more
Gaps in guideline adherence: evaluating HLA-B*57:01 screening for abacavir sensitivity and the implementation of evidence-based HIV careon August 22, 2025 at 4:43 pm
Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): Lisa V. Kalman, Yang Xia, Ya-Lin A. Huang, Kate Buchacz, Rex Astles, Jesse O’Shea
An automatic chemiluminescence immunoassay for a novel biomarker NT-IGFBP-4: analytical performance and clinical relevance in heart failureShuzheng Caoon August 22, 2025 at 10:00 am
Clin Chem Lab Med. 2025 Aug 25. doi: 10.1515/cclm-2025-0378. Online ahead of print. ABSTRACT OBJECTIVES: Insulin-like growth factor binding protein-4 (IGFBP-4) fragments are reported as emerging biomarkers for cardiovascular disease (CVD) risk assessment. To ensure data reliability and improve clinical application, the first automatic chemiluminescent immunoassay (CLIA) for NT-IGFBP-4 was developed and its distribution across … Read more
An innovative immunoassay for accurate aldosterone quantification: overcoming low-level inaccuracy and renal dysfunction-associated interferenceKaijuan Wangon August 22, 2025 at 10:00 am
Clin Chem Lab Med. 2025 Aug 25. doi: 10.1515/cclm-2025-0743. Online ahead of print. ABSTRACT OBJECTIVES: Accurate quantification of aldosterone is critical for screening and diagnosing primary aldosteronism (PA). Current competitive chemiluminescence immunoassays (cCLIA) overestimate plasma aldosterone concentration (PAC) compared to liquid chromatography-tandem mass spectrometry (LC-MS/MS). However, LC-MS/MS is technically demanding and time-consuming, limiting its widespread … Read more
Validation of a plasma GFAP immunoassay and establishment of age-related reference values: bridging analytical performance and routine implementationBurak Arslanon August 22, 2025 at 10:00 am
Clin Chem Lab Med. 2025 Aug 25. doi: 10.1515/cclm-2025-0870. Online ahead of print. ABSTRACT OBJECTIVES: Glial fibrillary acidic protein (GFAP) is a well-established biomarker of astrocytic activation associated with neurodegenerative diseases, neuroinflammatory disorders, and traumatic brain injury. With increasing interest in blood-based biomarkers, the need for analytically validated assays and reliable reference intervals is critical … Read more
Method comparison of diabetes mellitus associated autoantibodies in serum specimensAlexander Lenardon August 22, 2025 at 10:00 am
Clin Chem Lab Med. 2025 Aug 25. doi: 10.1515/cclm-2025-0137. Online ahead of print. ABSTRACT OBJECTIVES: Autoantibodies against structure elements of the pancreas are an essential part of laboratory diagnosis of diabetes mellitus. The heterogeneity of current methods and difficult inter-assay comparability of results poses challenges to both clinical interpretation as well as research integrity. METHODS: … Read more
Monitoring treatment response using serial PTX3 levels in chronic and invasive pulmonary aspergillosison August 22, 2025 at 9:44 am
Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Shiang-Fen Huang, Fu-Der Wang, Chia-Chang Huang, Kun-Ta Chou, Yu-Chi Huang, Ping-Feng Wu, Chen-Te Lee, Ying-Ying Yang
Combined clinical and genomic analysis uncovers neonatal-onset Wilson disease in two siblings with idiopathic cholestasison August 22, 2025 at 9:44 am
Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Boudour Khabou, Manel Guirat, Manel Hsairi, Lamia Gargouri, Slim Charfi, Mohamed Hadj Kacem, Tahia Boudawara, Hassen Kammoun, Faiza Fakhfakh, Hassen Hadj Kacem