Journal – Page 118 – Clinical Chemistry INFO

Quality assurance using patient split samples: recommendations for primary healthcare laboratoriesAnne Stavelinon August 25, 2025 at 10:00 am

August 25, 2025 by ccinfoadmin

Clin Chem Lab Med. 2025 Aug 26. doi: 10.1515/cclm-2025-0818. Online ahead of print. ABSTRACT OBJECTIVES: The increasing adoption of point-of-care testing (POCT) in primary healthcare highlights the need for robust quality assurance (QA) procedures to ensure result reliability. The patient split sample approach, i.e. comparing POCT and central laboratory results from the same patient, can … Read more

Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use

August 25, 2025 by ccinfoadmin

Clin Chem. 2025 Aug 25:hvaf094. doi: 10.1093/clinchem/hvaf094. Online ahead of print. ABSTRACT BACKGROUND: Protein biomarkers are routinely measured for disease diagnosis and prognosis in clinical laboratories. Since most assays focus on protein quantity, information about proteoforms is often not acquired. Proteoforms of a protein represent the complex integration of genetic polymorphism, alternative splicing of RNA … Read more

Critical role of laboratory and multidisciplinary strategies in the early diagnosis of acquired haemophilia a for life-saving managementon August 24, 2025 at 4:59 pm

August 24, 2025 by ccinfoadmin

Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): R. Belardi, M. Emili, F.G. Viola, S. Velocci, M. Baldetti, M. Minieri, M. Pieri, E. Picchi, D. Morosetti, S. Bernardini, A. Terrinoni

An improved and economical LLE-LC/MS method for quantifying phosphatidylethanol: Identification and separation of isotopic cross-talk in clinical alcohol testingon August 24, 2025 at 4:59 pm

August 24, 2025 by ccinfoadmin

Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): Naga Veera Yerra, Christopher Pini, Carlos Cordon-Cardo, Damodara Rao Mendu

Point-of-care devices for thin-film-based biosensors for the detection of glucose, urea, and pH in biological sampleson August 24, 2025 at 2:06 pm

August 24, 2025 by ccinfoadmin

Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Sandeep Choudhary, Tanmay Vyas, Abhijeet Joshi

Diagnostic utility of combined coagulation and inflammatory biomarkers in sepsis stratification: A retrospective studyon August 24, 2025 at 2:06 pm

August 24, 2025 by ccinfoadmin

Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Zhenzhen Ding, Qian Li, Chunyan Ma, Hang Li

Defining a clinically relevant thyroglobulin antibody interference threshold for high-sensitivity thyroglobulin immunoassays: a single institution case studyon August 23, 2025 at 5:05 pm

August 23, 2025 by ccinfoadmin

Publication date: October 2025 Source: Clinical Biochemistry, Volume 139 Author(s): Simmi Patel, Octavia M. Peck Palmer, Chanda B. Lay, Kathleen Mulvey, Michael R. Shurin, Sarah E. Wheeler

Falsely elevated FSH levels due to assay interference: a case-based approachon August 23, 2025 at 12:02 pm

August 23, 2025 by ccinfoadmin

Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Bünyamin Kanat, Gokce Atikeler, Elif Azarsiz

Survey on critical results management in Brazilian clinical laboratories: Profiling practices through multivariate analysis and a “New Statistics” approachon August 23, 2025 at 12:02 pm

August 23, 2025 by ccinfoadmin

Publication date: 1 January 2026 Source: Clinica Chimica Acta, Volume 578 Author(s): Alan Carvalho Dias, Derliane de Oliveira, Fernando de Almeida Berlitz, José Antônio Tesser Poloni, Wilson Shcolnik, Claudia Maria Meira Dias, Daniane Grando Remor Canalli, Luisane Maria Falci Vieira, Bruna Dolci Andreguetto, Felipe Magalhães Furtado, Rafael Monsores Lopes, Adriano Basques Fernandes, Leonardo de Souza … Read more

A Parametric Empirical Bayes Approach to Personalized Reference Intervals and Reference Change Values

August 22, 2025 by ccinfoadmin

Clin Chem. 2025 Aug 22:hvaf092. doi: 10.1093/clinchem/hvaf092. Online ahead of print. ABSTRACT BACKGROUND: Population-wide reference intervals (RIpop) are commonly used in laboratory medicine but may not reflect an individual’s tightly regulated homeostatic interval. Personalized reference intervals (RIper) could enhance diagnostic precision by accounting for individual variability. A parametric empirical Bayes (PEB) framework stabilizes individual estimates … Read more