Clinical Chemistry

Clin Chem. 2025 Jul 21:hvaf081. doi: 10.1093/clinchem/hvaf081. Online ahead of print. ABSTRACT BACKGROUND: Cell-free fetal DNA (cffDNA) screening exhibits higher sensitivity and lower false-positive rates (FPRs) compared to combined first-trimester screening for common trisomies. However, additional anomalies on other autosomes detected by genome-wide assays cause anxiety and trigger increased rates of amniocentesis. Here, we evaluated … Read more

Clin Chem. 2025 Jul 18:hvaf074. doi: 10.1093/clinchem/hvaf074. Online ahead of print. ABSTRACT BACKGROUND: Iron deficiency (ID) is a prevalent global health issue with a major impact on well-being. Early detection of ID is crucial but challenging due to its nonspecific symptoms and the limitations of traditional diagnostic tests, which are impractical for large-scale screening. This … Read more

Clin Chem. 2025 Jul 15:hvaf077. doi: 10.1093/clinchem/hvaf077. Online ahead of print. ABSTRACT BACKGROUND: High-sensitivity cardiac troponin (hs-cTn) assays are prone to negative and positive interferences caused by endogenous cardiac troponin-specific autoantibodies (cTnAAbs). Large macrotroponin complexes formed of cardiac troponin (cTn) and cTnAAbs may result in falsely elevated hs-cTn results. This is potentially due to reduced … Read more

Clin Chem. 2025 Jul 9:hvaf073. doi: 10.1093/clinchem/hvaf073. Online ahead of print. ABSTRACT BACKGROUND: Cardiovascular guidelines have long recommended low-density lipoprotein-cholesterol (LDL-C) as the primary target for lipid-lowering therapy. Recent guidelines have emphasized the importance of achieving low LDL-C levels; hence, the accurate measurement of low LDL-C is increasingly clinically relevant. METHODS: Using lipid panel test … Read more

Clin Chem. 2025 Jul 8:hvaf078. doi: 10.1093/clinchem/hvaf078. Online ahead of print. NO ABSTRACT PMID:40626709 | DOI:10.1093/clinchem/hvaf078

Clin Chem. 2025 Jul 4;71(7):737-740. doi: 10.1093/clinchem/hvae223. NO ABSTRACT PMID:40613799 | DOI:10.1093/clinchem/hvae223

Clin Chem. 2025 Jul 4;71(7):821-823. doi: 10.1093/clinchem/hvaf048. NO ABSTRACT PMID:40613798 | DOI:10.1093/clinchem/hvaf048

Clin Chem. 2025 Jul 4;71(7):740-741. doi: 10.1093/clinchem/hvaf010. NO ABSTRACT PMID:40613797 | DOI:10.1093/clinchem/hvaf010

Clin Chem. 2025 Jul 4;71(7):741-742. doi: 10.1093/clinchem/hvaf036. NO ABSTRACT PMID:40613796 | DOI:10.1093/clinchem/hvaf036

Clin Chem. 2025 Jul 4;71(7):824-825. doi: 10.1093/clinchem/hvaf040. NO ABSTRACT PMID:40613795 | DOI:10.1093/clinchem/hvaf040