Clin Chem. 2025 Nov 11:hvaf147. doi: 10.1093/clinchem/hvaf147. Online ahead of print. ABSTRACT BACKGROUND: The increasing reports of xylazine in clinical and postmortem toxicology necessitate a survey of its clinical impact. This review examines reports of xylazine across the peer-reviewed literature and grey literature (government and public health reports). CONTENT: Before 2005, reports of xylazine abuse … Read more
Clin Chem. 2025 Nov 7:hvaf136. doi: 10.1093/clinchem/hvaf136. Online ahead of print. ABSTRACT BACKGROUND: Duchenne and Becker muscular dystrophies are X-linked neuromuscular disorders caused by mutations in the dystrophin gene (DMD). Duplications account for approximately 10% of pathogenic variants, but their structural complexity and variable clinical impact present significant challenges in pathogenicity interpretation. METHODS: We retrospectively … Read more
Clin Chem. 2025 Nov 6:hvaf142. doi: 10.1093/clinchem/hvaf142. Online ahead of print. ABSTRACT BACKGROUND: NPM1 is a disease-defining gene in the diagnosis of acute myeloid leukemia (AML) and is important for measurable residual disease (MRD) assessment. Over 50 different NPM1 mutations have been described, but only the 3 most common are routinely monitored during follow-up. METHODS: … Read more
Clin Chem. 2025 Nov 4:hvaf119. doi: 10.1093/clinchem/hvaf119. Online ahead of print. ABSTRACT BACKGROUND: Despite almost 3 decades of research, the mechanisms underlying the bidirectional trafficking of cells at the maternal-fetal interface that gives rise to microchimerism remain poorly understood. A major barrier to progress has been the lack of suitable detection methods capable of distinguishing … Read more
Clin Chem. 2025 Nov 4;71(11):1105-1108. doi: 10.1093/clinchem/hvaf096. NO ABSTRACT PMID:41184091 | DOI:10.1093/clinchem/hvaf096
Clin Chem. 2025 Nov 4;71(11):1178-1179. doi: 10.1093/clinchem/hvaf084. NO ABSTRACT PMID:41184090 | DOI:10.1093/clinchem/hvaf084
Clin Chem. 2025 Nov 4;71(11):1176-1177. doi: 10.1093/clinchem/hvaf113. NO ABSTRACT PMID:41184089 | DOI:10.1093/clinchem/hvaf113
Clin Chem. 2025 Nov 4;71(11):1109. doi: 10.1093/clinchem/hvaf107. NO ABSTRACT PMID:41184088 | DOI:10.1093/clinchem/hvaf107
Clin Chem. 2025 Nov 4;71(11):1110. doi: 10.1093/clinchem/hvaf108. NO ABSTRACT PMID:41184087 | DOI:10.1093/clinchem/hvaf108
Clin Chem. 2025 Oct 23:hvaf111. doi: 10.1093/clinchem/hvaf111. Online ahead of print. ABSTRACT BACKGROUND: Flow cytometry is a crucial diagnostic tool in hematopathology. It supports the identification and follow-up of hematolymphoid neoplasms by providing detailed immunophenotypic data and quantification, and is applicable to various specimen types. CONTENT: Classification and management of acute myeloid leukemia (AML), the … Read more
