Optimizing Estimation: Perspective on Drug Dosing Using New CKD-EPI Equations
Clin Chem. 2025 Mar 29:hvaf031. doi: 10.1093/clinchem/hvaf031. Online ahead of print. NO ABSTRACT PMID:40156901 | DOI:10.1093/clinchem/hvaf031
Clinical Chemistry
Vitamin B12 Deficiency and New Recommendations by the National Institute for Health and Care Excellence: A Challenging Clinical and Laboratory Topic
Clin Chem. 2025 Mar 27:hvaf037. doi: 10.1093/clinchem/hvaf037. Online ahead of print. NO ABSTRACT PMID:40152469 | DOI:10.1093/clinchem/hvaf037
HOPEing That a PEACEful Resolution for the Clinical Utility of High-Sensitivity Cardiac Troponin in the Ambulatory Setting Will Improve Laboratory Testing
Clin Chem. 2025 Mar 27:hvaf034. doi: 10.1093/clinchem/hvaf034. Online ahead of print. NO ABSTRACT PMID:40151089 | DOI:10.1093/clinchem/hvaf034
A Meta-Analysis and Systematic Review of Cardiac Troponin I vs T in Community Dwelling Adults: Is Specificity at Risk?
Clin Chem. 2025 Mar 27:hvaf023. doi: 10.1093/clinchem/hvaf023. Online ahead of print. ABSTRACT BACKGROUND: Cardiac troponin I and T measured by high-sensitivity assays (hs-cTn) are detectable in most ambulatory adults. Hs-cTnI and T may perform differently for prediction of cardiovascular (CV) events. In adults with myopathies and advanced age, hs-cTnT can lose CV specificity. We undertook … Read more
Placental Biomarker Testing for Evaluation of Suspected Preeclampsia
Clin Chem. 2025 Mar 25:hvaf024. doi: 10.1093/clinchem/hvaf024. Online ahead of print. ABSTRACT BACKGROUND: Worldwide, hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and neonatal morbidity and mortality (Semin Perinatol 2009;33:130-7). This is especially true in the United States where preeclampsia is a leading cause of premature births (Hypertens Pregnancy 2016;35:510-9 and Lancet … Read more
The Economics of Cell-Free DNA Metagenomic Next-Generation Sequencing for Pathogen Detection
Clin Chem. 2025 Mar 24:hvaf027. doi: 10.1093/clinchem/hvaf027. Online ahead of print. NO ABSTRACT PMID:40126871 | DOI:10.1093/clinchem/hvaf027
Incidental Findings of Maternal Cancer in Noninvasive Prenatal Testing through Cell-Free DNA Sequencing
Clin Chem. 2025 Mar 21:hvaf014. doi: 10.1093/clinchem/hvaf014. Online ahead of print. NO ABSTRACT PMID:40116646 | DOI:10.1093/clinchem/hvaf014
Determinants of Cardiac Myosin Binding Protein C in the General Population
Clin Chem. 2025 Mar 20:hvaf013. doi: 10.1093/clinchem/hvaf013. Online ahead of print. ABSTRACT BACKGROUND: Cardiac myosin binding protein C (cMyC) is a novel, cardiac-specific biomarker with an early release profile after acute ischemic myocardial injury. Whether cMyC reflects chronic myocardial injury and left ventricular remodelling in the general population is unknown. The aims of the study … Read more
Carbamylated Albumin, Heart Failure, and Mortality in Patients Undergoing Coronary Angiography
Clin Chem. 2025 Mar 19:hvaf021. doi: 10.1093/clinchem/hvaf021. Online ahead of print. ABSTRACT BACKGROUND: Urea is elevated in chronic kidney disease (CKD) and end-stage renal disease (ESRD), and promotes the carbamylation of proteins, including human albumin, on multiple lysine side chains. Higher proportions of carbamylated albumin (C-Alb) have been associated with increased mortality risk in patients … Read more
Pediatric Vaccine-Induced Antibody Thresholds: Rethinking Pre-Immunosuppression Serologic Testing and Revaccination Implications
Clin Chem. 2025 Mar 19:hvaf020. doi: 10.1093/clinchem/hvaf020. Online ahead of print. ABSTRACT BACKGROUND: Immune response to vaccination is assessed when adequate vaccine protection is in question or immunosuppression is imminent through measurement of antibody levels, which wane as time from vaccination increases. The serologic cutoff value for adequate response is based on thresholds derived from … Read more