Clinical Chemistry

Cardiac Troponin I and T Ratio and Risk of Cardiovascular or Non-Cardiovascular Events in a General Population

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Clin Chem. 2025 Feb 19:hvaf016. doi: 10.1093/clinchem/hvaf016. Online ahead of print. ABSTRACT BACKGROUND: Emerging evidence suggests that the ratio between cardiac troponin (cTn) I and T may provide information on the risk of adverse outcomes in individuals with cardiovascular disease. Whether the cTn I/T ratio provides prognostic insights in the general population is unknown. METHODS: … Read more

Direct-to-Consumer Testing: Benefits and Concerns of Commercially Accessed Laboratory Tests

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Clin Chem. 2025 Feb 18:hvaf004. doi: 10.1093/clinchem/hvaf004. Online ahead of print. ABSTRACT BACKGROUND: Promoting self-empowerment of patients and of healthy persons in contemporary health cultures shifts the imperative for initiating laboratory tests from the healthcare professionals (HCP) to the patients themselves. CONTENT: Laboratory testing requested directly by patients without interaction by HCP is called DTCT … Read more

Laboratory Monitoring in Transgender and Gender-Diverse Individuals

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Clin Chem. 2025 Mar 3;71(3):358-377. doi: 10.1093/clinchem/hvaf001. ABSTRACT BACKGROUND: Increasing numbers of transgender and gender-diverse individuals are seeking initiation of gender-affirming hormone therapy. This aligns an individual’s physical characteristics with their gender identity and improves psychological outcomes. Physical changes, including changes to muscle mass and body fat redistribution, can alter sex-specific laboratory reference ranges. CONTENT: … Read more

Enrichment of Microbial DNA in Plasma to Improve Pathogen Detection in Sepsis: A Pilot Study

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Clin Chem. 2025 Mar 11:hvaf011. doi: 10.1093/clinchem/hvaf011. Online ahead of print. ABSTRACT BACKGROUND: Diagnosis of sepsis and timely identification of pathogens in critically ill patients remains challenging. Plasma metagenomic sequencing to detect microbial cell-free DNA (mDNA) has shown promise, but low abundance of mDNA in plasma limits sensitivity and necessitates high sequencing depth. mDNA is … Read more

Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants by an Improved Full-Length ABO Haplotype Sequencing

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Clin Chem. 2025 Mar 6:hvaf015. doi: 10.1093/clinchem/hvaf015. Online ahead of print. ABSTRACT BACKGROUND: Full-length ABO haplotype sequencing is crucial for accurate genotyping, reference gene annotation, and molecular mechanism analysis of its variants. However, there is currently a deficiency of comprehensive annotation for full-length ABO haplotypes, spanning from the 5′ untranslated region (UTR) to the 3′ … Read more

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