Influence of Macrotroponin on the 99th Percentile Threshold in 2 High-Sensitivity Cardiac Troponin Assays

Clin Chem. 2025 Jun 10:hvaf068. doi: 10.1093/clinchem/hvaf068. Online ahead of print. ABSTRACT BACKGROUND: Cardiac troponin (cTn) levels exceeding the 99th percentile upper reference limit and a rise/fall pattern are key for diagnosing myocardial injury and infarction. Macrotroponins, formed by patient anti-cTn antibodies targeting cTn, can cause persistently elevated cTn levels without ongoing myocardial injury. The … Read more

Discordance between Cystatin C-Based and Creatinine-Based Estimated Glomerular Filtration Rate and Mortality in the General Population

Clin Chem. 2025 Jun 4:hvaf063. doi: 10.1093/clinchem/hvaf063. Online ahead of print. ABSTRACT BACKGROUND: The consequences for health outcomes of the discordance in cystatin C-based (eGFRcys) and creatinine-based (eGFRcr) estimated glomerular filtration rates are gaining attention. However, the association of discordance with all-cause mortality in the general population has not been explored. METHODS: A total of … Read more

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