Clinical Chemistry

0/2 h-Algorithm for Rapid Triage of Suspected Myocardial Infarction Using a Novel High-Sensitivity Cardiac Troponin I Assay

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Clin Chem. 2022 Feb 1;68(2):303-312. doi: 10.1093/clinchem/hvab203. ABSTRACT BACKGROUND: We aimed to derive and validate a 0/2 h-algorithm using the new high-sensitivity cardiac troponin I (hs-cTnI)-VITROS assay (VITROS® Immunodiagnostic Products hs-Troponin I Reagent Pack, Ortho Clinical Diagnostics) for rapid rule-out/in of non-ST-segment elevation myocardial infarction (NSTEMI). METHODS: The final diagnosis was centrally adjudicated by 2 … Read more

Diagnosis of Drug-Resistant Tuberculosis: Rapid Evaluation of Drug Susceptibility with Nanopore Targeted Sequencing

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Clin Chem. 2025 May 27:hvaf061. doi: 10.1093/clinchem/hvaf061. Online ahead of print. ABSTRACT BACKGROUND: Whole-genome sequencing (WGS) has limitations in clinical diagnostics due to host DNA interference and lower pathogen load in clinical samples compared to cultured isolates, which reduce the effective sequencing depth and compromise the detection of resistance-associated mutations. As our understanding of the … Read more

Full-Length Clonal Immunoglobulin Rearrangements in cfDNA: Improved Recovery and Sequencing

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Clin Chem. 2025 May 26:hvaf064. doi: 10.1093/clinchem/hvaf064. Online ahead of print. ABSTRACT BACKGROUND: Circulating tumor DNA present in cell-free DNA (cfDNA) serves as diagnostic, predictive, and prognostic markers in cancer patients. In lymphoma patients, clonal immunoglobulin (cIg) sequences enable accurate identification of disease states. Despite its importance, there is sparse literature surrounding the preanalytical and … Read more

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