Clinical Chemistry

Instrument Multiplexing: Amplified Throughput for Measurement of Vitamin B1 in Whole Blood Using Parallel Liquid Chromatography Systems Interfaced to a Single Mass Spectrometer

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Clin Chem. 2025 Apr 9:hvaf029. doi: 10.1093/clinchem/hvaf029. Online ahead of print. ABSTRACT BACKGROUND: Thiamine diphosphate (TDP), the active form of vitamin B1, plays an essential role in energy metabolism. TDP is analyzed in the clinical laboratory to assess the nutritional status of individuals at risk of deficiency. In recent years, demand for vitamin B1 testing … Read more

Methylglyoxal-Induced Glycation of Plasma Albumin: From Biomarker Discovery to Clinical Use for Prediction of New-Onset Diabetes in Individuals with Prediabetes

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Clin Chem. 2025 Apr 7:hvaf035. doi: 10.1093/clinchem/hvaf035. Online ahead of print. ABSTRACT BACKGROUND: Methylglyoxal (MGO) is a potent glycating agent that contributes to the pathogenesis of diabetes. However, MGO is unstable in plasma without demanding sample preparation at blood collection, limiting its clinical utility as a biomarker. We aimed to discover reliable MGO-glycated albumin (ALB)-derived … Read more

Correlations Within and Between Highly Multiplexed Proteomic Assays of Human Plasma

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Clin Chem. 2025 Apr 2:hvaf030. doi: 10.1093/clinchem/hvaf030. Online ahead of print. ABSTRACT INTRODUCTION: The number of assays on proteomic platforms has grown rapidly. The leading platforms, SomaScan and Olink, have strengths and limitations. Comparisons of precision on the latest platforms-SomaScan 11k and Olink Explore HT-have not yet been established. METHODS: Among 102 participants in the … Read more

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