Commentary on Increased Salicylate Concentration in a Patient Reporting No Aspirin Use
Clin Chem. 2026 Mar 5;72(3):335-336. doi: 10.1093/clinchem/hvaf179. NO ABSTRACT PMID:41784382 | DOI:10.1093/clinchem/hvaf179
Clinical Chemistry
Elevated Creatinine-Cause for Concern or False Alarm?
Clin Chem. 2026 Mar 5;72(3):422-423. doi: 10.1093/clinchem/hvaf140. NO ABSTRACT PMID:41784381 | DOI:10.1093/clinchem/hvaf140
A Culture-Free Lipidomics-Based Screening Test for Uropathogens
Clin Chem. 2026 Mar 5;72(3):381-389. doi: 10.1093/clinchem/hvaf164. ABSTRACT BACKGROUND: A rapid culture-free method is needed to improve diagnostic efficiency and guide timely antimicrobial therapy for urinary tract infections (UTIs). Previously, we utilized the lipidomics-based fast lipid analysis technique (FLAT) to screen for uropathogens by identifying distinctive microbial membrane lipid profiles, specifically lipid A in gram-negative … Read more
Correction to: Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?
Clin Chem. 2026 Feb 27:hvag015. doi: 10.1093/clinchem/hvag015. Online ahead of print. NO ABSTRACT PMID:41758357 | DOI:10.1093/clinchem/hvag015
A Digital PCR Assay for Fetal Fraction Quantification Using Multiplex SNP and Y Chromosome Detection
Clin Chem. 2026 Feb 26:hvag017. doi: 10.1093/clinchem/hvag017. Online ahead of print. ABSTRACT BACKGROUND: Fetal fraction (FF) quantification is critical for prenatal cell-free DNA screening. Current methods based on Y chromosome (chrY), differential methylation, or single-nucleotide polymorphisms (SNPs) face limitations including sex dependency, complex workflows, or the need for parental genotyping. An FF quantification method that … Read more
Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine
Clin Chem. 2026 Feb 26:hvag014. doi: 10.1093/clinchem/hvag014. Online ahead of print. ABSTRACT BACKGROUND: Clinical laboratory measurements provide essential results for prediction, screening, diagnosing, treating, monitoring, and prognosis of patients. To ensure patient safety, laboratory professionals must define appropriate analytical requirements for each measurand, including measurement uncertainty, selectivity, traceability, and robustness. Performance specifications should ensure that … Read more
Correction to: Discordance between Cystatin C-Based and Creatinine-Based Estimated Glomerular Filtration Rate and Mortality in the General Population
Clin Chem. 2026 Feb 26:hvag003. doi: 10.1093/clinchem/hvag003. Online ahead of print. NO ABSTRACT PMID:41740614 | DOI:10.1093/clinchem/hvag003
Cardiac Biomarker Kinetics in Patients after Coronary Artery Bypass Grafting with an Uncomplicated Course
Clin Chem. 2026 Feb 24:hvag012. doi: 10.1093/clinchem/hvag012. Online ahead of print. ABSTRACT BACKGROUND: The definition of periprocedural myocardial infarction (PMI) after coronary artery bypass grafting (CABG) remains debated, particularly regarding the use of cardiac troponins vs creatine kinase MB isoform (CK-MB), and biomarker thresholds seem outdated [10×, 35×, or 70× multiples of upper reference limits … Read more
Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets
Clin Chem. 2026 Feb 23:hvaf192. doi: 10.1093/clinchem/hvaf192. Online ahead of print. ABSTRACT BACKGROUND: Quantum machine learning (QML) is an emerging field that may offer unique advantages over classical machine learning but has not been extensively studied with real-world healthcare data of practical size. This study evaluates the performance of a recently proposed quantum machine learning … Read more
All for One and One for All? The Role of RNA-Based Next-Generation Sequencing in the Molecular Profiling of Tumors
Clin Chem. 2026 Feb 23:hvag009. doi: 10.1093/clinchem/hvag009. Online ahead of print. NO ABSTRACT PMID:41725611 | DOI:10.1093/clinchem/hvag009