Clinical Chemistry

Pre-Exposure Prophylaxis (PrEP)-Associated HIV Monitoring and Self-Testing

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Clin Chem. 2025 Dec 3:hvaf155. doi: 10.1093/clinchem/hvaf155. Online ahead of print. ABSTRACT BACKGROUND: Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) encompasses the use of antiviral medications to prevent HIV acquisition in individuals without HIV who are at risk. Currently available HIV PrEP medications are nucleoside reverse transcriptase inhibitors and integrase inhibitors. HIV testing is required … Read more

Impact of Clinical Variables on cfDNA Fragmentomic Signatures and Their Potential as Confounders in Cancer Detection

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Clin Chem. 2025 Dec 2:hvaf163. doi: 10.1093/clinchem/hvaf163. Online ahead of print. ABSTRACT BACKGROUND: Circulating cell-free DNA (cfDNA) fragmentomic features, such as fragment size and end motifs, have emerged as promising noninvasive biomarkers for cancer detection. However, the influence of nonmalignant clinical factors on these features remains unclear, potentially confounding liquid biopsy assays. METHODS: We analyzed … Read more

Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?

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Clin Chem. 2025 Nov 13:hvaf162. doi: 10.1093/clinchem/hvaf162. Online ahead of print. ABSTRACT BACKGROUND: Phosphorylated tau 217 (p-tau217) has emerged as a leading blood-based biomarker for Alzheimer disease (AD). While typically measured in plasma, serum is a widely used matrix in clinical laboratories, yet few p-tau217 assays have been validated for serum. Evaluating serum p-tau217 performance … Read more

Per Se Driving Under the Influence of Cannabis Statutes and Blood Delta-9-Tetrahydrocannabinol Concentrations following Short-Term Cannabis Abstinence

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Clin Chem. 2025 Nov 12:hvaf121. doi: 10.1093/clinchem/hvaf121. Online ahead of print. ABSTRACT BACKGROUND: Several US states have per se laws using 2 or 5 ng/mL of delta-9-tetrahydrocannabinol (THC) as cutpoints for driving under the influence of cannabis, while some have zero-tolerance statutes. These cutpoints are considered prima facia evidence of driving impairment. METHODS: In a … Read more

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