Clinical Chemistry

eGFR Inaccuracy in the Assessment of Living Kidney Transplant Donor Eligibility

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Clin Chem. 2025 Jun 18:hvaf071. doi: 10.1093/clinchem/hvaf071. Online ahead of print. ABSTRACT BACKGROUND: Accurate glomerular filtration rate (GFR) estimation is crucial for evaluating living kidney donors, especially when measured GFR (mGFR) is unavailable. This study compares the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), full age spectrum (FAS), and European Kidney Function Consortium (EKFC) creatinine- and/or … Read more

Cell-Free DNA Comprises the Strand-Specific Characteristic Associated with Transcription and Methylation

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Clin Chem. 2025 Jun 16:hvaf070. doi: 10.1093/clinchem/hvaf070. Online ahead of print. ABSTRACT BACKGROUND: Cell-free DNA (cfDNA) is a promising biomarker and carries information about physiological and pathological states. Nucleosome and transcription factor footprints have been extensively studied based on double-stranded cfDNA sequencing; however, protein-DNA interaction footprints in single-stranded cfDNA fragments remain undercharacterized. METHODS: We used … Read more

Advances in Syphilis Diagnostics to Address the 21st-Century Epidemic

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Clin Chem. 2025 Jun 13:hvaf072. doi: 10.1093/clinchem/hvaf072. Online ahead of print. ABSTRACT BACKGROUND: For 20 years, the United States has experienced a progressive rise in syphilis cases, increasing to >209 000 cases in 2023. The current case rate of 62.5 per 100 000 persons represents a 30-fold increase since 2000-2001, when a concerted national effort … Read more

Optimal Value of Mutant KRAS Circulating Tumor DNA for Predicting Prognosis and Monitoring in Patients with Pancreatic Adenocarcinoma: A Prospective Multicenter Cohort Study

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Clin Chem. 2025 Jun 13:hvaf066. doi: 10.1093/clinchem/hvaf066. Online ahead of print. ABSTRACT BACKGROUND: The generalizability and applicability of circulating tumor DNA (ctDNA) KRAS mutations in patients with pancreatic adenocarcinoma (PAC) remain elusive. We aimed to propose a cut-off value of mutant KRAS (mKRAS) concentration in ctDNA and validate its clinical utility. METHODS: This prospective, multicenter … Read more

Influence of Macrotroponin on the 99th Percentile Threshold in 2 High-Sensitivity Cardiac Troponin Assays

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Clin Chem. 2025 Jun 10:hvaf068. doi: 10.1093/clinchem/hvaf068. Online ahead of print. ABSTRACT BACKGROUND: Cardiac troponin (cTn) levels exceeding the 99th percentile upper reference limit and a rise/fall pattern are key for diagnosing myocardial injury and infarction. Macrotroponins, formed by patient anti-cTn antibodies targeting cTn, can cause persistently elevated cTn levels without ongoing myocardial injury. The … Read more

Discordance between Cystatin C-Based and Creatinine-Based Estimated Glomerular Filtration Rate and Mortality in the General Population

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Clin Chem. 2025 Jun 4:hvaf063. doi: 10.1093/clinchem/hvaf063. Online ahead of print. ABSTRACT BACKGROUND: The consequences for health outcomes of the discordance in cystatin C-based (eGFRcys) and creatinine-based (eGFRcr) estimated glomerular filtration rates are gaining attention. However, the association of discordance with all-cause mortality in the general population has not been explored. METHODS: A total of … Read more

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