Clinical Chemistry

Modern Low-Density Lipoprotein Cholesterol Formulas Outperform Direct Methods in Patients with Hypertriglyceridemia and Low Levels of Low-Density Lipoprotein Cholesterol

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Clin Chem. 2025 Sep 3:hvaf099. doi: 10.1093/clinchem/hvaf099. Online ahead of print. ABSTRACT BACKGROUND: Direct measurement of low-density lipoprotein cholesterol (LDL-C) is widely used and recommended by professional society guidelines despite its potential limitations in patients with hypertriglyceridemia and low LDL-C. This study evaluated the performance of 3 direct LDL-C (LDL-CD) assays, 2 modern LDL-C calculation … Read more

Machine Learning Algorithms for Predicting Urinary Tract Infections: Integration of Demographic Data and Dipstick Reflectance Results

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Clin Chem. 2025 Aug 26:hvaf088. doi: 10.1093/clinchem/hvaf088. Online ahead of print. ABSTRACT BACKGROUND: Urinary tract infections (UTIs) are among the most common infections encountered in healthcare settings. Current diagnostic practices often require 24-48 h due to the time needed for culture results. Given that 70%-80% of cultures return negative, there is significant interest in rapidly … Read more

In Vitro Metabolic Profiling of 18 Semi-Synthetic Cannabinoids-Hexahydrocannabinol (HHC) and Its Analogs-with Identification in an Authentic Hexahydrocannabiphorol (HHCP) Urine Sample

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Clin Chem. 2025 Aug 25:hvaf087. doi: 10.1093/clinchem/hvaf087. Online ahead of print. ABSTRACT BACKGROUND: Hexahydrocannabinol (HHC) and its analogs are recent additions to semi-synthetic cannabinoids in the recreational drug market. Here, the metabolism of 18 HHC analogs was compared to gain a comprehensive understanding of the structure-metabolism relationship of HHC analogs and to identify urinary biomarkers. … Read more

Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use

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Clin Chem. 2025 Aug 25:hvaf094. doi: 10.1093/clinchem/hvaf094. Online ahead of print. ABSTRACT BACKGROUND: Protein biomarkers are routinely measured for disease diagnosis and prognosis in clinical laboratories. Since most assays focus on protein quantity, information about proteoforms is often not acquired. Proteoforms of a protein represent the complex integration of genetic polymorphism, alternative splicing of RNA … Read more

A Parametric Empirical Bayes Approach to Personalized Reference Intervals and Reference Change Values

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Clin Chem. 2025 Aug 22:hvaf092. doi: 10.1093/clinchem/hvaf092. Online ahead of print. ABSTRACT BACKGROUND: Population-wide reference intervals (RIpop) are commonly used in laboratory medicine but may not reflect an individual’s tightly regulated homeostatic interval. Personalized reference intervals (RIper) could enhance diagnostic precision by accounting for individual variability. A parametric empirical Bayes (PEB) framework stabilizes individual estimates … Read more

Interdisciplinary Collaboration to Develop a Custom Genomic Analysis Pipeline for the Clinical Laboratory: Hepatitis B Virus and Cytomegalovirus Antiviral Resistance Genotyping

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Clin Chem. 2025 Aug 21:hvaf093. doi: 10.1093/clinchem/hvaf093. Online ahead of print. ABSTRACT BACKGROUND: Next-generation sequencing for hepatitis B virus (HBV) and cytomegalovirus (CMV) antiviral drug resistance (AVDR) testing improves the sensitivity of variant detection, but availability of bioinformatics and analytical pipelines are key barriers to implementation. METHODS: Plasma was extracted on MagNA Pure 24 (Roche … Read more

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