Clinical Chemistry

Urine Cell-Free RNA vs Plasma Cell-Free RNA for Monitoring of Kidney Injury and Immune Complications

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Clin Chem. 2025 Aug 12:hvaf082. doi: 10.1093/clinchem/hvaf082. Online ahead of print. ABSTRACT BACKGROUND: There is increasing interest in the use of circulating cell-free RNA (cfRNA) in plasma as an analyte for diagnosing and monitoring disease. While it is known that cfRNA can also be isolated from urine, the diagnostic potential of urine cfRNA, particularly relative … Read more

Allelic Cataloging of RHD-RHCE Reference Sequences Using Targeted Long-Read Sequencing

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Clin Chem. 2025 Aug 8:hvaf090. doi: 10.1093/clinchem/hvaf090. Online ahead of print. ABSTRACT BACKGROUND: Implementation of blood group genotyping has offered substantial benefits in transfusion medicine. However, the complex molecular basis of Rh antigen expression and a high degree of sequence homology between RHD and RHCE have long limited the accuracy of blood group genotyping, highlighting … Read more

Gene Therapy for Hemophilias: Opportunities and Challenges for the Clinical Laboratory

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Clin Chem. 2025 Aug 7:hvaf085. doi: 10.1093/clinchem/hvaf085. Online ahead of print. ABSTRACT BACKGROUND: Hemophilia A and B are X-linked coagulation disorders characterized by low or dysfunctional Factor VIII (FVIII) or IX (FIX), respectively. Currently, hemophilia A and B are treated by FVIII/FIX replacement therapy with plasma-derived or recombinant products or by FVIII-mimetic agents (e.g., emicizumab). … Read more

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