Clinical Chemistry

A Modified Sampson-NIH Equation with Improved Accuracy for Estimating Low Levels of Low-Density Lipoprotein-Cholesterol

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Clin Chem. 2025 Jul 9:hvaf073. doi: 10.1093/clinchem/hvaf073. Online ahead of print. ABSTRACT BACKGROUND: Cardiovascular guidelines have long recommended low-density lipoprotein-cholesterol (LDL-C) as the primary target for lipid-lowering therapy. Recent guidelines have emphasized the importance of achieving low LDL-C levels; hence, the accurate measurement of low LDL-C is increasingly clinically relevant. METHODS: Using lipid panel test … Read more

Allele-Specific Digital PCR Enhances Precision and Sensitivity in the Detection and Quantification of Copy Number Alterations in Heterogeneous DNA Samples

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Clin Chem. 2025 Jun 19:hvaf054. doi: 10.1093/clinchem/hvaf054. Online ahead of print. ABSTRACT BACKGROUND: While genetic analyses are vital in cancer diagnostics, measuring copy number (CN) alterations remains challenging, especially in heterogenous samples such as (liquid) biopsies. Using digital PCR, CN alterations are classically studied by comparing the abundances of the target of interest to a … Read more

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