Clinical Chemistry

Assessment of Placental Chromosomal Mosaicism during Prenatal Cell-Free DNA Screening Refines Positive Predictive Values for Fetal Trisomy

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Clin Chem. 2025 Jul 28:hvaf076. doi: 10.1093/clinchem/hvaf076. Online ahead of print. ABSTRACT BACKGROUND: Confined placental mosaicism can cause false-positive prenatal cell-free DNA (cfDNA) screening results, thereby reducing the positive predictive value (PPV) of the test. We sought to investigate how PPVs for the common fetal trisomies can be refined based on the presence or absence … Read more

Continuous Glucose Monitors Have Acceptable Accuracy but High Discordance at High and Low Glucose Concentrations in Pediatric Hospitalized Patients

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Clin Chem. 2025 Jul 25:hvaf080. doi: 10.1093/clinchem/hvaf080. Online ahead of print. ABSTRACT BACKGROUND: Continuous glucose monitors (CGMs) assess interstitial glucose concentrations and improve diabetes management in outpatient settings. However, limited studies have assessed CGM performance in hospitalized pediatric patients, especially at high and low glucose thresholds near clinical decision limits. METHODS: This retrospective study included … Read more

Diagnostic Value of Digital Estimates of Trophoblastic Mosaicism in Genome-Wide Cell-Free Fetal DNA Screening

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Clin Chem. 2025 Jul 21:hvaf081. doi: 10.1093/clinchem/hvaf081. Online ahead of print. ABSTRACT BACKGROUND: Cell-free fetal DNA (cffDNA) screening exhibits higher sensitivity and lower false-positive rates (FPRs) compared to combined first-trimester screening for common trisomies. However, additional anomalies on other autosomes detected by genome-wide assays cause anxiety and trigger increased rates of amniocentesis. Here, we evaluated … Read more

Machine Learning for Detecting Iron Deficiency through Comprehensive Blood Analysis

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Clin Chem. 2025 Jul 18:hvaf074. doi: 10.1093/clinchem/hvaf074. Online ahead of print. ABSTRACT BACKGROUND: Iron deficiency (ID) is a prevalent global health issue with a major impact on well-being. Early detection of ID is crucial but challenging due to its nonspecific symptoms and the limitations of traditional diagnostic tests, which are impractical for large-scale screening. This … Read more

Exploring the Role of Cardiac Troponin-Specific Autoantibodies: Prolonged Cardiac Troponin Elimination, Reduced Clearance, and Variable Interference across 5 Commercial Assays

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Clin Chem. 2025 Jul 15:hvaf077. doi: 10.1093/clinchem/hvaf077. Online ahead of print. ABSTRACT BACKGROUND: High-sensitivity cardiac troponin (hs-cTn) assays are prone to negative and positive interferences caused by endogenous cardiac troponin-specific autoantibodies (cTnAAbs). Large macrotroponin complexes formed of cardiac troponin (cTn) and cTnAAbs may result in falsely elevated hs-cTn results. This is potentially due to reduced … Read more

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