Clinical Chemistry and Laboratory Medicine

Multi-analytical identification of the synthetic opioids cychlorphine and methiodone (IC-26) in drug seizures: first detection in EuropePaméla Dugueson January 8, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 12. doi: 10.1515/cclm-2025-1428. Online ahead of print. ABSTRACT OBJECTIVES: The rapid emergence of highly potent synthetic opioids represents a growing challenge for forensic and clinical laboratories. METHODS: We report the first identification in Europe of methiodone (IC-26) and the first detection in France of cychlorphine in drug samples collected … Read more

Establishment of allowable total error for semen analysis based on the state of the art in ChinaYan Zhengon January 8, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 9. doi: 10.1515/cclm-2025-1222. Online ahead of print. ABSTRACT OBJECTIVES: To establish evidence-based analytical performance specifications (APS), specifically allowable total error (TEa), for five fundamental semen analysis parameters (sperm concentration, progressive motility, total motility, morphology, and vitality) in China utilizing the state-of-the-art model, and to compare these specifications with existing … Read more

Contribution of SuPAR for patients in a situation of uncertainty downstream of emergenciesMarina Brailovaon January 8, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 9. doi: 10.1515/cclm-2025-1101. Online ahead of print. ABSTRACT OBJECTIVES: Evolution is difficult to predict for some patients at emergency department (ED). The soluble urokinase plasminogen activator receptor (suPAR) is a non-specific prognostic inflammatory blood biomarker with a high negative predictive value for pejorative outcomes. The aim of this study … Read more

Secondary use of external quality assessment data – estimating inter-assay variation in LOINC-coded datasetsMichael Vogeseron January 7, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 8. doi: 10.1515/cclm-2025-1695. Online ahead of print. ABSTRACT The secondary scientific use of routine laboratory data will increasingly rely on LOINC as a semantic standard, particularly within the European Health Data Space (EHDS). LOINC enables the aggregation of large data sets from clinical care for research purposes, particularly in … Read more

Comparison of blood sample quality and test results between robotic and manual venipuncture: a pilot studyRong Wangon January 7, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 8. doi: 10.1515/cclm-2025-1126. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to evaluate the feasibility of robotic venipuncture in clinical settings and compare its performance with manual venipuncture in terms of blood specimen quality and test results. METHODS: From March to April 2025, 63 participants (35 females, 28 … Read more

Evaluation of the MAGLUMI non-competitive angiotensin I chemiluminescence immunoassay for measuring renin activity in human plasmaLina Wuon January 6, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 7. doi: 10.1515/cclm-2025-1361. Online ahead of print. ABSTRACT OBJECTIVES: Plasma renin activity (PRA) measures the rate of renin converting angiotensinogen to angiotensin I in circulation and reflects the function of renin-angiotensin-aldosterone system (RAAS). The study aimed to demonstrate the performance of the MAGLUMI Angiotensin I assay for the measurement … Read more

Assessment of drone transport for biological samples: a real-world experience at a tertiary hospitalPaula Calomarde-Pastoron January 5, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 6. doi: 10.1515/cclm-2025-1205. Online ahead of print. ABSTRACT OBJECTIVES: Our aim is to determine whether drone transport introduces relevant variability in analytical results and to assess its suitability for integration into routine hospital laboratory operations. METHODS: A two-phase study was conducted. The stability phase involved three sets of samples … Read more

Applying the Implementation Science to the harmonization of laboratory test results in the changing landscapeMauro Panteghinion January 4, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 6. doi: 10.1515/cclm-2025-1632. Online ahead of print. ABSTRACT Nowadays, we are facing major changes in the landscape of test harmonization through metrological traceability approach, all expected to promote equivalence of reported laboratory results. However, having traceability tools in place does not automatically mean that metrological traceability is correctly implemented. … Read more

Measurement of lipoprotein(a) via a novel point of care approach with comparison to established laboratory assaysCaroline A E Bachmeieron January 4, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 6. doi: 10.1515/cclm-2025-1605. Online ahead of print. ABSTRACT OBJECTIVES: Lipoprotein(a) is an atherogenic particle causative of atherosclerotic cardiovascular disease. Novel treatments have been developed that lower lipoprotein(a) to unprecedented levels with cardiovascular outcomes trials ongoing. Many guidelines recommend testing once in the lifetime of everyone, but testing rates remain … Read more

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