Clin Chem Lab Med. 2025 Apr 8. doi: 10.1515/cclm-2025-0264. Online ahead of print. ABSTRACT OBJECTIVES: Macroprolactin (macro-PRL) mostly comprises a complex of PRL with IgG. The aim of this study was to clarify whether IgA-type macro-PRL exists and, if so, to elucidate the prevalence of and differences in laboratory data from IgG-type. METHODS: One hundred … Read more
Clin Chem Lab Med. 2025 Apr 7. doi: 10.1515/cclm-2024-1312. Online ahead of print. ABSTRACT OBJECTIVES: Primary aldosteronism (PA) is a common cause of secondary hypertension. The aldosterone-to-renin ratio (ARR) is the current recommended biomarker for PA screening, but it has limitations. This study evaluates another ratio, the aldosterone-to-angiotensin II ratio (AAIIR), as an alternative screening … Read more
Clin Chem Lab Med. 2025 Apr 7. doi: 10.1515/cclm-2025-0177. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to investigate the prevalence of macroprolactinemia and the changes in hyperprolactinemia status over time among hyperprolactinemic patients in the Turkish population. METHODS: A retrospective study was conducted on 3,013 patient records from a central university hospital between … Read more
Clin Chem Lab Med. 2025 Apr 4. doi: 10.1515/cclm-2025-0163. Online ahead of print. ABSTRACT OBJECTIVES: Recent advances in information technology have renewed interest in patient-based real-time quality control (PBRTQC) as an alternative to internal quality control (IQC). However, since regulations mandate IQC, PBRTQC can only be implemented as a separate system. The additional labor required … Read more
Clin Chem Lab Med. 2025 Mar 31. doi: 10.1515/cclm-2025-0117. Online ahead of print. ABSTRACT OBJECTIVES: The stability of plasma samples for basic coagulation tests, prothrombin time (PT) and activated partial thromboplastin time (aPTT), has been widely studied. Recently, the Clinical and Laboratory Standards Institute (CLSI) updated its recommendations, extending the acceptable time frame for aPTT. … Read more
Clin Chem Lab Med. 2025 Mar 25. doi: 10.1515/cclm-2024-1387. Online ahead of print. ABSTRACT OBJECTIVES: We determined the efficacy of a high sensitivity cardiac troponin I (hs-cTnI) assay for newly derived 0 h and 0/2-h rule-out concentrations for myocardial infarction and determined the safety of incremental changes at low concentrations. METHODS: Consecutive, emergency department patients … Read more
Clin Chem Lab Med. 2025 Mar 25. doi: 10.1515/cclm-2025-0317. Online ahead of print. NO ABSTRACT PMID:40123562 | DOI:10.1515/cclm-2025-0317
Clin Chem Lab Med. 2025 Mar 24. doi: 10.1515/cclm-2024-1428. Online ahead of print. ABSTRACT OBJECTIVES: The insulin-like growth factors (IGFs) regulate growth in humans. IGF-I and IGF binding protein (IGFBP)-3 are biomarkers in children with growth disorders. We investigate a targeted proteomics method for absolute quantitation of eight IGF protein family members in human serum, … Read more
Clin Chem Lab Med. 2025 Mar 24. doi: 10.1515/cclm-2025-0291. Online ahead of print. NO ABSTRACT PMID:40116362 | DOI:10.1515/cclm-2025-0291
Clin Chem Lab Med. 2025 Mar 21. doi: 10.1515/cclm-2025-0032. Online ahead of print. ABSTRACT OBJECTIVES: The Certified Reference Material (CRM) ERM®-DA477/IFCC is a new polyclonal IgG anti-beta2-glycoprotein I (anti-β2GPI) material for the harmonization of the laboratory diagnosis of antiphospholipid syndrome (APS). We evaluated CRM’s ability to represent the heterogeneity of APS patient anti-β2GPI antibodies and … Read more
