Clinical Chemistry and Laboratory Medicine

Automation in value-based laboratory medicine: driving precision, capacity, and better outcomesDamien Grusonon January 13, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 15. doi: 10.1515/cclm-2026-0023. Online ahead of print. ABSTRACT Laboratory medicine lies at the core of modern healthcare, enabling timely diagnosis, effective patient monitoring, and increasingly personalized therapeutic strategies. Over the past decades, automation has profoundly reshaped the role of clinical laboratories, substantially enhancing their contribution to clinical outcomes, operational … Read more

One copy in one-pot for rapid and accurate SFTSV testing by LAC12b-2MYa Pangon January 13, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 14. doi: 10.1515/cclm-2025-0791. Online ahead of print. ABSTRACT OBJECTIVES: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne pathogen that can cause a fatality rate as high as 12-50 %, posing a significant threat to public health. SFTSV is prevalent in mountainous and hilly regions with relatively poor … Read more

Comparability, compatibility, equivalence and interchangeability: metrological concepts widely misunderstood in laboratory medicineRaúl Rigo-Bonninon January 9, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 12. doi: 10.1515/cclm-2025-1644. Online ahead of print. ABSTRACT BACKGROUND: Method-comparison studies in laboratory medicine are routinely interpreted using regression-based or Bland-Altman analyses. Although useful descriptively, these statistical procedures are frequently misapplied to infer “agreement”, “equivalence”, or “interchangeability”. Such interpretations overlook essential metrological conditions – including the definition of the … Read more

Multi-analytical identification of the synthetic opioids cychlorphine and methiodone (IC-26) in drug seizures: first detection in EuropePaméla Dugueson January 8, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 12. doi: 10.1515/cclm-2025-1428. Online ahead of print. ABSTRACT OBJECTIVES: The rapid emergence of highly potent synthetic opioids represents a growing challenge for forensic and clinical laboratories. METHODS: We report the first identification in Europe of methiodone (IC-26) and the first detection in France of cychlorphine in drug samples collected … Read more

Establishment of allowable total error for semen analysis based on the state of the art in ChinaYan Zhengon January 8, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 9. doi: 10.1515/cclm-2025-1222. Online ahead of print. ABSTRACT OBJECTIVES: To establish evidence-based analytical performance specifications (APS), specifically allowable total error (TEa), for five fundamental semen analysis parameters (sperm concentration, progressive motility, total motility, morphology, and vitality) in China utilizing the state-of-the-art model, and to compare these specifications with existing … Read more

Contribution of SuPAR for patients in a situation of uncertainty downstream of emergenciesMarina Brailovaon January 8, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 9. doi: 10.1515/cclm-2025-1101. Online ahead of print. ABSTRACT OBJECTIVES: Evolution is difficult to predict for some patients at emergency department (ED). The soluble urokinase plasminogen activator receptor (suPAR) is a non-specific prognostic inflammatory blood biomarker with a high negative predictive value for pejorative outcomes. The aim of this study … Read more

Secondary use of external quality assessment data – estimating inter-assay variation in LOINC-coded datasetsMichael Vogeseron January 7, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 8. doi: 10.1515/cclm-2025-1695. Online ahead of print. ABSTRACT The secondary scientific use of routine laboratory data will increasingly rely on LOINC as a semantic standard, particularly within the European Health Data Space (EHDS). LOINC enables the aggregation of large data sets from clinical care for research purposes, particularly in … Read more

Comparison of blood sample quality and test results between robotic and manual venipuncture: a pilot studyRong Wangon January 7, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 8. doi: 10.1515/cclm-2025-1126. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to evaluate the feasibility of robotic venipuncture in clinical settings and compare its performance with manual venipuncture in terms of blood specimen quality and test results. METHODS: From March to April 2025, 63 participants (35 females, 28 … Read more

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