Clinical Chemistry and Laboratory Medicine

Lipoprotein X as a source of analytical and interpretative interference in routine laboratory testingShanshan Liangon August 14, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 17. doi: 10.1515/cclm-2026-0950. Online ahead of print. ABSTRACT Lipoprotein X (LpX) is an abnormal lipoprotein-like particle occurring mainly in cholestasis, lecithin-cholesterol acyltransferase deficiency, post-transplant cholestatic liver dysfunction, hepatic graft-versus-host disease, and selected intravenous lipid emulsion or parenteral nutrition settings. Enrichment in phospholipids and unesterified cholesterol, paucity of cholesteryl esters … Read more

A liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of vancomycin in human serum and plasmaSandra Fleischeron August 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 12. doi: 10.1515/cclm-2026-0509. Online ahead of print. ABSTRACT OBJECTIVES: Vancomycin is a glycopeptide antibiotic used to treat severe Gram-positive infections; its narrow therapeutic window makes therapeutic drug monitoring (TDM) critical. We report the development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) candidate reference measurement procedure (RMP) to quantify vancomycin … Read more

Harmonizing M-protein analysis: an international, multi-center reproducibility study of mass spectrometry and evaluation of concordance to electrophoretic methodsKatie Thorenon August 10, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 11. doi: 10.1515/cclm-2026-0844. Online ahead of print. ABSTRACT OBJECTIVES: Serum M-protein analysis is central to the assessment of monoclonal gammopathies. Quantitation and isotyping are commonly performed by SPE or CZE and IFE or IT, respectively. While these assays are widely used, they are characterized by limited sensitivity and subjective … Read more

Therapeutic monoclonal antibodies mimicking paraproteins in immunofixation electrophoresis: migration profiles of 21 commonly used agentsMarie-Léa Kabouon August 10, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 11. doi: 10.1515/cclm-2026-0777. Online ahead of print. ABSTRACT OBJECTIVES: Therapeutic monoclonal antibodies (t-mAbs) are increasingly used in oncology, hematology, autoimmune diseases, and inflammatory disorders. Because most of these agents are monoclonal immunoglobulins, they may be detected by serum immunofixation electrophoresis (IFE) and mimic pathological monoclonal proteins. METHODS: We analyzed … Read more

IOF-IFCC international survey of global laboratory practices for bone status indicesEtienne Cavalieron August 6, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Aug 7. doi: 10.1515/cclm-2026-0941. Online ahead of print. ABSTRACT OBJECTIVES: Bone status indices (BSIs) are increasingly used in metabolic bone disease, yet global laboratory practices remain poorly characterized. Building on recent IOF-IFCC nomenclature and ESCEO-IOF-IFCC recommendations, we conducted an international descriptive survey of BSI practices. METHODS: A cross-sectional web-based questionnaire … Read more

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