Clinical Chemistry and Laboratory Medicine – Page 7

Impact of a computerized intervention to optimize laboratory tests ordering: one-year follow-up in a geriatric unitEdith Rengueton July 10, 2026 at 10:00 am

July 10, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0938. Online ahead of print. ABSTRACT OBJECTIVES: Approximately 30 % of laboratory tests are ordered inappropriately, substantially impacting patient care, costs, and carbon footprint of laboratories. Predefined laboratory test panels are a pragmatic and routinely used tool in laboratories, where tests are bundled for efficiency to diagnose … Read more

Looking back to look forward: can analytical performance be successfully linked to health outcomes in laboratory medicine?Katy J L Bellon July 10, 2026 at 10:00 am

July 10, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0643. Online ahead of print. ABSTRACT The 2015 Milan consensus proposed three models for analytical performance (APS) specifications for laboratory tests. Model 1 recommends defining analytical performance specifications based on impact on clinical outcomes. We undertook a targeted literature review to identify and evaluate studies using indirect … Read more

Laboratory Medicine for SocietyTomáš Zimaon July 9, 2026 at 10:00 am

July 10, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0977. Online ahead of print. ABSTRACT This collective opinion paper, based on presentations delivered during the two-day European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Strategic Conference 2026, “Laboratory Medicine for Society” (Prague, Czech Republic, 24-25 April 2026) offers a forward-looking overview of the Federation’s strategic … Read more

Systematic bias in point-of-care INR testing: comparative analysis of Abbott and Roche devicesSandya Arunachalamon July 9, 2026 at 10:00 am

July 9, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0408. Online ahead of print. ABSTRACT OBJECTIVES: Point-of-care (POC) International Normalised Ratio (INR) testing provides rapid anticoagulation monitoring. Still, it is susceptible to systematic bias, particularly at supratherapeutic levels, which can lead to inappropriate warfarin dose adjustments and increased thrombotic risk. This study evaluated bias trends between … Read more

Introduction of new calibrator lots for quantitative protein mass spectrometry and adjustment of calibration settings for long term multiplex apolipoproteins quantificationNico P M Smiton July 8, 2026 at 10:00 am

July 9, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2025-0872. Online ahead of print. ABSTRACT OBJECTIVES: Calibration is a cornerstone of clinical chemistry test results and maintaining an in-house LDT requires periodic renewal of calibrators. Here we present the introduction of a new set of native human serum calibrators, using different curve fitting approaches for long-term … Read more

Detection of M-protein by iMS-IP and iMS-FLC assays redefines previously non-secretory POEMS syndromeYuan Huangon July 8, 2026 at 10:00 am

July 9, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jul 10. doi: 10.1515/cclm-2026-0489. Online ahead of print. ABSTRACT OBJECTIVES: In polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome, when monoclonal plasma cell proliferation is absent, it is considered ‘non-secretory POEMS syndrome’. We aimed to study whether M-protein was detectable by mass spectrometry (MS) in previously non-secretory POEMS syndrome. … Read more

A revised approach to data modelling for patient classification to determine analytical performance specifications based on Milan 1bGraham Ross Dallas Joneson July 8, 2026 at 10:00 am

July 8, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jul 9. doi: 10.1515/cclm-2026-0444. Online ahead of print. ABSTRACT A widely accepted approach to setting Analytical Performance Specifications (APS) in laboratory medicine is the Milan models. The Milan Model 1b is an approach in which APS are developed based on patient classification or clinical decision-making, noting that these factors are … Read more

Assessing neonatal and paediatric acute kidney injury: current practices and insights from the IFCC C-ETPLM International Laboratory SurveyTim Langon July 8, 2026 at 10:00 am

July 8, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jul 9. doi: 10.1515/cclm-2026-0626. Online ahead of print. ABSTRACT OBJECTIVES: Identification of acute kidney injury (AKI) in neonatology and paediatrics continues to present challenges to laboratories. Emerging biomarkers are being developed which may offer early detection but haven’t been adopted in current guidelines yet. The aim of this IFCC survey … Read more

A novel comprehensive non-invasive prenatal testing system for the simultaneous detection of single-gene disorders, chromosomal structural rearrangements, and aneuploidyYichen Zhangon July 8, 2026 at 10:00 am

July 8, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jul 9. doi: 10.1515/cclm-2025-1488. Online ahead of print. ABSTRACT OBJECTIVES: Invasive prenatal diagnosis is recommended for high-risk pregnancies, but many decline due to potential complications. To date, no non-invasive prenatal testing (NIPT) simultaneously detects monogenic diseases, balanced chromosomal rearrangements (BCRs), and aneuploidies. We developed a comprehensive NIPT to detect monogenic … Read more

Fish-shaped erythrocytes and pincer cells co-occur in distinct hematological disorders and are associated with anemia severityAnna Lena Lembeckon July 6, 2026 at 10:00 am

July 6, 2026 by ccinfoadmin

Clin Chem Lab Med. 2026 Jul 7. doi: 10.1515/cclm-2026-0957. Online ahead of print. ABSTRACT OBJECTIVES: Red blood cell (RBC) morphology in peripheral blood smears (PBS) remains essential for the differential diagnosis of anemia and other hematologic disorders. As yet unclassified poikilocytes, fish-shaped RBCs and pincer (mushroom-shaped) cells are rarely observed but have been described as … Read more