Clinical Chemistry and Laboratory Medicine

Age- and sex-specific reference intervals for 11-oxygenated androgens from infancy throughout childhood and adulthoodRobert Zeidleron February 16, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 17. doi: 10.1515/cclm-2025-1440. Online ahead of print. ABSTRACT OBJECTIVES: The adrenal glands are the main source of 11-oxygenated androgens (11-OAs), including the potent 11-ketotestosterone (11-KT) and the weaker metabolites 11β-hydroxyandrostenedione (11-OHA4), 11β-hydroxytestosterone (11-OHT) and 11-ketoandrostenedione (11-KA4). Due to their adrenal origin, 11-OAs allow the differentiation of adrenal and extra-adrenal-produced … Read more

From ordering to interpretation: a comprehensive framework for laboratory test indicationsJasmin Weningeron February 16, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 6. doi: 10.1515/cclm-2025-1531. Online ahead of print. ABSTRACT OBJECTIVES: Clinical intent for laboratory testing (“indication”) is rarely recorded in structured form, limiting contextual interpretation, auditability, and utilization stewardship. We developed a comprehensive, and clinically applicable framework that standardizes laboratory test indications and links them to indication-dependent utilization and interpretation. … Read more

Antiphosphatidylserine/prothrombin antibodies define a high-risk antiphospholipid syndrome profile associated with organ damageAriela Hoxhaon February 3, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 3. doi: 10.1515/cclm-2025-1565. Online ahead of print. ABSTRACT OBJECTIVES: Antiphosphatidylserine/prothrombin (aPS/PT) antibodies are promising non-criteria aPLs associated with antiphospholipid syndrome (APS) manifestations. Their influence on long-term outcomes and damage remains uncertain. To assess aPS/PT antibodies association with accrual damage and severe APS disease phenotypes, focusing on their potential for … Read more

Blood biomarkers in neurodegenerative diseases: pre-analytical, analytical, and post-analytical challengesConstance Delabyon February 3, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 3. doi: 10.1515/cclm-2025-1731. Online ahead of print. ABSTRACT Recent advances in blood-based biomarkers for neurodegenerative diseases present promising opportunities for earlier diagnosis and more effective disease monitoring. However, challenges in standardizing sample collection, processing protocols, and data reporting continue to hinder reproducibility, limit cross-study comparability, and delay clinical adoption. … Read more

Green laboratory through test ordering appropriateness and innovationSveva Stangalinion February 3, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 3. doi: 10.1515/cclm-2025-1606. Online ahead of print. ABSTRACT OBJECTIVES: Clinical laboratories play a vital role in healthcare but are also among the most resource-intensive hospital units. High energy and water consumption, extensive use of single-use plastics, and the generation of non-recyclable biomedical waste present major environmental challenges. This study … Read more

Implementation of AI systems in the clinical laboratory: insights from an expert survey and recommendations for best practiceHe S Yangon February 3, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 3. doi: 10.1515/cclm-2025-1322. Online ahead of print. ABSTRACT OBJECTIVES: Despite growing interest in artificial intelligence (AI) and machine learning (ML), many laboratory professionals lack experience with developing in-house AI systems or implementing those supplied by external providers. The IFCC Committee on AI in Laboratory Medicine (C-AILM) conducted a survey … Read more

Laboratory solution to diagnose and monitor atypical IgG4-mediated anti-GBM diseaseJoannes F M Jacobson February 1, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 2. doi: 10.1515/cclm-2025-1499. Online ahead of print. ABSTRACT OBJECTIVES: Diagnosing atypical IgG4-mediated anti-glomerular basement membrane (anti-GBM) disease is challenging because conventional serological assays poorly detect IgG4 antibodies. Here we study which commercial assays are affected and we describe proof-of-concept of improved IgG4 anti-GBM detection. METHODS: To investigate the scope … Read more

Effect of storage conditions on NSE, S100, and B2M stability in cerebrospinal fluid and serumNatalia García-Sanchaon January 27, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 28. doi: 10.1515/cclm-2025-1320. Online ahead of print. ABSTRACT OBJECTIVES: The reliability of cerebrospinal fluid (CSF) and serum biomarkers depends on sample integrity, which is strongly influenced by storage conditions. While -80 °C is considered the gold standard for long-term preservation, it requires specialized infrastructure, whereas -20 °C is more … Read more

Predicting congenital hypothyroidism in newborns with complex risk profiles by using thyroid-stimulating hormone variations across serial dried blood spotsLaura Cappellettion January 27, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 28. doi: 10.1515/cclm-2025-1387. Online ahead of print. ABSTRACT OBJECTIVES: Newborn screening for congenital hypothyroidism (CH) relies on thyroid-stimulating hormone (TSH) levels from dried blood spots (DBS). We investigated whether incorporating TSH variation across serial DBS could improve prediction of CH in term and preterm infants with complex risk profiles. … Read more

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