Clinical Chemistry and Laboratory Medicine

Laboratory findings in patients treated with complement factor C3 inhibitor pegcetacoplanSaskia M C Langemeijeron January 2, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 5. doi: 10.1515/cclm-2025-1270. Online ahead of print. ABSTRACT OBJECTIVES: Complement inhibitor pegcetacoplan binds to C3 and its activation product C3b. Pegcetacoplan has been approved for the treatment of paroxysmal nocturnal hemoglobinuria. Because pegcetacoplan exerts broad inhibition of the complement cascade its efficacy is also investigated in numerous other diseases … Read more

At-home blood collection for clinical chemistry analyses in a kidney transplant population: a feasibility studyJorrit Hoekstraon January 2, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 5. doi: 10.1515/cclm-2025-1199. Online ahead of print. ABSTRACT OBJECTIVES: To investigate the feasibility of at-home collection of liquid capillary blood samples for clinical chemistry analyses. METHODS: Kidney transplant recipients performed a fingerprick to collect capillary blood samples. Samples were kept at room temperature for 24 h before further processing. … Read more

Analytical and diagnostic evaluation of the Anvajo fluidlab 2 analyzer: a novel urine particle analyzer for clinical application using digital holographic microscopy?Sigrid Deprezon January 2, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 2. doi: 10.1515/cclm-2025-1202. Online ahead of print. ABSTRACT OBJECTIVES: The performance of a novel urine particle analyzer, fluidlab 2 (Anvajo GmbH, Dresden, Germany), was evaluated against phase-contrast visual microscopy according to the most recent EFLM European Urinalysis Guideline. METHODS: The fluidlab 2 device combines digital holographic microscopy with neural … Read more

Impact of pneumatic tube system transport and blood collection tubes on cell-free DNA analysis of plasma samplesLuisa Matos do Cantoon December 30, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Oct 9;64(2):332-342. doi: 10.1515/cclm-2025-0367. Print 2026 Jan 29. ABSTRACT OBJECTIVES: Transporting blood samples with pneumatic tube systems (PTSs) is routine in many hospitals. The influence of PTS transport on cell-free DNA (cfDNA) and circulating tumor DNA (ctDNA) analyses has not been comprehensively tested. METHODS: Paired blood samples from non-patient donors … Read more

Flow cytometry, cytology and histology in the diagnosis of ocular hematologic neoplasms: a 15-year monocentric experience with a focus on ocular lymphomasAlessandra Faldaon December 30, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Oct 9;64(2):489-504. doi: 10.1515/cclm-2025-0216. Print 2026 Jan 29. ABSTRACT OBJECTIVES: Ocular lymphomas are rare diseases that occur in ocular adnexa or specific intraocular regions. Although histology remains the gold standard, cytology and flow cytometry (FCM) are fundamental, mainly when a biopsy sampling is technically demanding. This study evaluated the effectiveness … Read more

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