Clinical Chemistry and Laboratory Medicine

Oral salt loading combined with postural stimulation tests for confirming and subtyping primary aldosteronismJenny Yeuk Ki Chengon August 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0644. Online ahead of print. ABSTRACT OBJECTIVES: Primary aldosteronism (PA) is an underdiagnosed yet important condition. This study aimed to evaluate the diagnostic performance of a combined protocol using oral salt loading and postural stimulation tests (PST), named the balance study, to confirm and subtype PA. METHODS: … Read more

Clinical validation of a liquid chromatography single quadrupole mass spectrometry (LC-MS) method using Waters Kairos™ Amino Acid Kit reagentsRowan Hellieron August 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0424. Online ahead of print. ABSTRACT OBJECTIVES: Quantitation of plasma amino acids (AA) is critical for the diagnosis and monitoring of inherited disorders of AA metabolism. AA analysis using ion-exchange chromatography (IEC) with post-column ninhydrin derivatization is time consuming, with run times of ∼2 h, limiting sample … Read more

A novel corrective model based on red blood cells indices and haemolysis index enables accurate unhaemolysed potassium determination in haemolysed samples – Hemokalc projectCharles R Lefèvreon August 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0330. Online ahead of print. ABSTRACT OBJECTIVES: Haemolysis is a major preanalytical issue that affects potassium measurements, often leading to sample rejection and delayed clinical management. This study proposes a novel corrective model for accurate unhaemolysed potassium prediction. METHODS: Blood samples from 14 healthy volunteers were used … Read more

Total laboratory automation: fit for its intended purposes?Mario Plebanion August 7, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0855. Online ahead of print. ABSTRACT Since the 1980s, automation has profoundly transformed clinical laboratory operations, enhancing efficiency, standardization, and throughput. This technological evolution has enabled laboratories to meet rising testing demands, address persistent workforce shortages, and control operational costs. Beyond analytical consolidation, significant progress has been … Read more

Establishment of region-, age- and sex-specific reference intervals for aldosterone and renin with sandwich chemiluminescence immunoassaysLin-Lin Caoon August 7, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0587. Online ahead of print. ABSTRACT OBJECTIVES: Accurate measurement of plasma aldosterone (ALD) and renin is important in primary aldosteronism screening and diagnosis. The high variability of ALD and renin due to salt intake, age, and sex, as well as the lack of immunoassay standardization necessitates the … Read more

Investigation of the possible cause of over-estimation of human aldosterone in plasma, using a unique, non-synthetic human aldosterone-free matrixSheree Stoneron July 31, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 1. doi: 10.1515/cclm-2024-1468. Online ahead of print. ABSTRACT OBJECTIVES: Aldosterone is over-estimated by direct immunoassay when compared to assay by LC-MS/MS. We have investigated the mechanism for this over-estimation, using dichloromethane (DCM) extraction and a unique matrix of non-synthetic aldosterone-free plasma (ALFP). METHODS: Samples used were from patients with … Read more

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