Clinical Chemistry and Laboratory Medicine

S100B measurement in the maternal blood: a new promising tool for fetal well-being/distress monitoring?Laura Abellaon April 19, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 15. doi: 10.1515/cclm-2025-1673. Online ahead of print. ABSTRACT Adverse event in the perinatal period constitutes today the wider bulk of investigation. Perinatal asphyxia (PA) and prematurity are the common causes of injury of high risk pregnancies (HR) and can lead to perinatal death or cognitive and neuro-motor impairment in … Read more

Mitochondrial DNA copy number in leukocytes predicts long-term survival in prostate cancerTanja Langsenlehneron April 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 16. doi: 10.1515/cclm-2025-1464. Online ahead of print. ABSTRACT OBJECTIVES: Low mitochondrial DNA copy number (mtCN) in leukocytes is a predictor of all-cause mortality, independent of age and sex. For malignant diseases, results about the prognostic value of leukocyte mtCN have been conflicting. Aim of the present study was to … Read more

Improving clinical interpretation of serum alpha-fetoprotein in children: using continuous and discrete reference intervalsDien Minh Tranon April 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 15. doi: 10.1515/cclm-2026-0262. Online ahead of print. ABSTRACT OBJECTIVES: To establish discrete and continuous age-specific reference intervals for serum alpha-fetoprotein in children and to evaluate whether continuous modeling improves interpretation during early infancy, when concentrations decline rapidly. METHODS: In this prospective, cross-sectional study, serum alpha-fetoprotein was measured in 3,680 … Read more

Salivary testosterone reference intervals for adult women and menMirjam Kruijton April 17, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 15. doi: 10.1515/cclm-2026-0144. Online ahead of print. ABSTRACT OBJECTIVES: Testosterone is increasingly being measured in saliva due to the ease of collection, which puts a lower burden on patients and facilitates measurement in clinical and behavioral studies. Although the robustness of measuring testosterone in saliva using immunoassays has been … Read more

Feasibility of improving sLe(a)/CA 19-9 harmonization by recalibration: a simulation study using three EQA programsHuub H van Rossumon April 14, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 15. doi: 10.1515/cclm-2026-0155. Online ahead of print. ABSTRACT OBJECTIVES: The CA 19-9 tumor marker measures the sialylated Lewis a blood group antigen (sLe(a)) expressed on circulating proteins. CA 19-9 is primarily used to monitor pancreatic and gastrointestinal cancers. Studies have demonstrated the lack of comparability of CA 19-9 assays. … Read more

A simplified multitarget stool test for colorectal cancer and advanced precancerous lesion detectionShuizhi Xuon April 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0236. Online ahead of print. ABSTRACT OBJECTIVES: Multitarget stool tests are approved for colorectal cancer (CRC) screening. Here we developed a multitarget stool test based on the fecal immunochemical test (FIT) and two (NDRG4 and SDC2) DNA methylation markers with a simple calling algorithm. METHODS: FIT, quantitative … Read more

Analytical and clinical performance of the Flash10 molecular point-of-care system for detection of influenza A and B virusesSheng Zengon April 11, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0093. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate the analytical performance and clinical workflow efficiency of the Flash10 molecular point-of-care testing (POCT) system for the detection of influenza A (FluA) and influenza B (FluB) viruses. METHODS: Throat swab specimens from 178 individuals presenting with influenza-like symptoms … Read more

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