Clinical Chemistry and Laboratory Medicine

Evaluation of the Sysmex UC-1000 test strip reader: fit for purpose in a point-of-care setting?Jana Neirinckon July 22, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 23. doi: 10.1515/cclm-2026-0866. Online ahead of print. ABSTRACT OBJECTIVES: Urinalysis is essential for detecting kidney disease, urinary tract infections, and diabetes mellitus. Point-of-care testing enables rapid screening in decentralized settings and supports low-throughput laboratories. This study evaluated the Sysmex UC-1000 according to the 2023 EFLM urinalysis guidelines in a … Read more

Choosing Wisely – avoiding medical overuse: evidence assessment of recommendations on laboratory parametersCihan Berion July 21, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 21. doi: 10.1515/cclm-2026-0358. Online ahead of print. ABSTRACT OBJECTIVES: Launched in 2012, the Choosing Wisely initiative promotes evidence-based recommendations to reduce unnecessary tests and treatments. This study reviewed laboratory-related recommendations from five countries (USA, UK, Germany, Switzerland, and Austria) to assess their scientific validity. METHODS: Choosing Wisely websites were … Read more

Predictive value of serum biomarkers for first trimester prediction of preterm prelabour rupture of membranes (PPROM): a systematic review and meta-analysisMarion Rouzaireon July 20, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 21. doi: 10.1515/cclm-2026-0380. Online ahead of print. ABSTRACT INTRODUCTION: The identification of early biomarkers is a critical prerequisite for the development and optimization of preventive strategies targeting preterm prelabour rupture of membranes (pPROM). The aim of this systematic review was to evaluate first trimester serum biomarkers for predicting the … Read more

Prospective real-time implementation and verification of patient-based real-time quality control using average of normals in a tertiary hospital laboratorySe-Eun Kooon July 16, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 17. doi: 10.1515/cclm-2026-0201. Online ahead of print. ABSTRACT OBJECTIVES: Practical implementation of patient-based real-time quality control (PBRTQC) requires analyte- and institution-specific optimization. This study evaluated the operational feasibility of average-of-normals (AoN)-based PBRTQC through a structured selection process and prospective event-based validation. METHODS: PBRTQC monitoring was performed using the Average … Read more

Establishment of DBS-based reference intervals for vitamins, essential elements, and potentially toxic elements in Chinese adults from Hubei ProvinceMengtong Yangon July 15, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Jul 16. doi: 10.1515/cclm-2026-0511. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to establish a comprehensive panel of dried blood spot (DBS)-specific reference intervals (RIs) for vitamins, essential elements, and potentially toxic elements (PTEs) in Chinese adults, and to introduce a hierarchical decision framework for selecting between healthy- and … Read more

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