Clinical Chemistry and Laboratory Medicine

Performance evaluation of five large language models for assisting in the interpretation of urinalysis reports for kidney diseases: a real-world studyTao Liuon April 25, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 20. doi: 10.1515/cclm-2026-0435. Online ahead of print. ABSTRACT OBJECTIVES: Large language models (LLMs) show promise for interpreting laboratory reports, yet real-world validation remains limited. This study evaluated five advanced LLMs in interpreting urinalysis reports for kidney diseases using real-world clinical data, providing empirical evidence for the utility of LLM-assisted … Read more

Post-transplant ring sideroblasts are common in haploidentical peripheral blood stem cell transplantation but not linked to SF3B1 mutationsMarlene Hollensteinon April 26, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 22. doi: 10.1515/cclm-2026-0080. Online ahead of print. ABSTRACT OBJECTIVES: To determine the prevalence of erythroid dysplasia and ring sideroblasts (RS) after peripheral blood stem cell transplantation (PBSCT), stratified by transplant type, and to assess the association with SF3B1 mutations and event-free survival (EFS). METHODS: In a retrospective single-center study, … Read more

Reporting of pre-analytical variables affecting the determination of brain-derived neurotrophic factor (BDNF) in patients with stroke: a scoping reviewElisa Bevilacquaon April 25, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 21. doi: 10.1515/cclm-2026-0277. Online ahead of print. ABSTRACT INTRODUCTION: Brain-derived neurotrophic factor (BDNF) is a neurotrophin expressed in the central nervous system, where it supports synaptic plasticity, neuronal survival, and dendritic remodeling. Reduced circulating BDNF levels have been reported in several neurological and psychiatric disorders, increasing evidence links BDNF … Read more

ANA fluorescence patterns and low C4 are associated with higher antiphospholipid antibody serological intensity in routine diagnostic testingNikolaos Androulakison April 25, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 20. doi: 10.1515/cclm-2025-1709. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate whether antinuclear antibody (ANA) titre or HEp-2 fluorescence patterns are associated with antiphospholipid antibody (aPL) serological intensity, and to examine component-specific complement abnormalities – particularly low C4 – as laboratory correlates compatible with classical-pathway involvement. METHODS: This retrospective … Read more

High albumin sensitization drives uninterpretable basophil activation tests in cow’s milk allergyBenjamin Bonneton April 21, 2026 at 10:00 am

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Clin Chem Lab Med. 2026 Apr 13. doi: 10.1515/cclm-2026-0079. Online ahead of print. ABSTRACT OBJECTIVES: The basophil activation test (BAT) is increasingly used for diagnosing IgE-mediated food allergies, yet its performance in cow’s milk allergy (CMA) remain insufficiently characterized in real-world pediatric practice. This study evaluates the diagnostic accuracy of BAT for CMA and identifies … Read more

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