Clinical Chemistry and Laboratory Medicine

Clin Chem Lab Med. 2026 Jul 29. doi: 10.1515/cclm-2026-0815. Online ahead of print. ABSTRACT OBJECTIVES: External quality assessment (EQA) is essential for ensuring reliable biochemical genetic testing. This study evaluated long-term performance trends in ERNDIM quantitative EQA schemes, including special assays in serum (SAS), special assays in urine (SAU), purines and pyrimidines in urine (PPU), … Read more

Clin Chem Lab Med. 2026 Jul 29. doi: 10.1515/cclm-2026-0185. Online ahead of print. ABSTRACT OBJECTIVES: Colorectal cancer (CRC) screening is crucial for early detection, yet the invasiveness of the gold-standard colonoscopy limits compliance. To address the limitation, this study proposes a novel multi-target free DNA methylation model and evaluated its risk stratification performance for CRC … Read more

Clin Chem Lab Med. 2026 Jul 28. doi: 10.1515/cclm-2026-0570. Online ahead of print. ABSTRACT OBJECTIVES: Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Emerging lung cancer screening in smokers may offer an opportunity for simultaneous cardiovascular risk evaluation. We developed a mobile CT screening unit and assessed the feasibility of integrating dyslipidemia screening … Read more

Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0864. Online ahead of print. ABSTRACT INTRODUCTION: To analyse the structural and operational divergences between NF EN ISO 15189:2022 and Regulation (EU) 2017/746 on in vitro diagnostic medical devices (IVDR) in the context of medical laboratory practice in Europe. CONTENT: This article provides a structured comparative analysis … Read more

Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0790. Online ahead of print. ABSTRACT OBJECTIVES: Understanding whether the novel long-T ITC complex might assist in interpreting clinical prognostic utility compared to established cardiac biomarkers is needed. We determined long term major adverse cardiac events (MACE) and all-cause mortality (ACM) predicated on novel long-T ITC complex … Read more

Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0863. Online ahead of print. ABSTRACT OBJECTIVES: Biological variation (BV) data are essential for many purposes in laboratory medicine, however, the complex statistical analysis remains a barrier for delivery of BV data. This study describes the development of a web-based BV Calculator based on the Biological Variation … Read more

Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0627. Online ahead of print. ABSTRACT OBJECTIVES: Accurate interpretation of pediatric laboratory test results requires robust age- and sex-specific reference intervals (RIs). Undertaking studies to establish RIs across the pediatric age range is particularly challenging due to rapid physiological changes during growth and development. While the Roche … Read more

Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0926. Online ahead of print. NO ABSTRACT PMID:42492590 | DOI:10.1515/cclm-2026-0926

Clin Chem Lab Med. 2026 Jul 27. doi: 10.1515/cclm-2026-0903. Online ahead of print. ABSTRACT Laboratory medicine is undergoing a profound transformation driven by advances in artificial intelligence (AI), automation, and data interoperability. By 2050, laboratories may evolve from analytical testing facilities into an interconnected health intelligence capable of translating biological, digital, and environmental data into … Read more

Clin Chem Lab Med. 2026 Jul 23. doi: 10.1515/cclm-2026-0704. Online ahead of print. ABSTRACT OBJECTIVES: Most available data on human chorionic gonadotropin (hCG) elevations in menopausal women are derived from studies using Roche assays, with limited evidence across other immunoassay platforms. This study aimed to establish assay-specific reference values for hCG and evaluate the impact … Read more