Clinical Chemistry and Laboratory Medicine

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of testosterone in human serum and plasmaElie Fuxon February 18, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 6. doi: 10.1515/cclm-2024-1266. Online ahead of print. ABSTRACT OBJECTIVES: This study presents a candidate reference measurement procedure (RMP) for testosterone quantification in human serum and plasma, utilizing isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC MS/MS). METHODS: The developed LC-MS/MS method employs a two-dimensional heart-cut LC approach combined with solid-phase extraction … Read more

The ARRplus: a model for renin-dependent and sex-specific aldosterone cut-offs that improves screening for primary aldosteronismSybille Fuldon February 16, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 17. doi: 10.1515/cclm-2025-1670. Online ahead of print. ABSTRACT OBJECTIVES: Screening for primary aldosteronism (PA) using the aldosterone:renin ratio (ARR) has suboptimal diagnostic accuracy, particularly in females. We assessed whether accuracy could be improved using sex-specific relationships of aldosterone with renin. METHODS: Plasma aldosterone and renin were measured in 442 … Read more

Personalized reference intervals based on biological variation for serum bone turnover markers in healthy older adultsYe Qinon February 16, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 12. doi: 10.1515/cclm-2025-1138. Online ahead of print. ABSTRACT OBJECTIVES: The clinical utility of serum bone turnover markers (BTMs) in managing osteoporosis in the elderly is constrained by the absence of personalized reference intervals (prRI) based on biological variation (BV). METHODS: This longitudinal study tracked monthly serum levels of β-CTX, … Read more

Optimizing diagnostic thresholds of total vitamin B12 (B12) for identifying cobalamin deficiency in adults with macrocytic anemiaMichela Pellosoon February 16, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 13. doi: 10.1515/cclm-2025-1722. Online ahead of print. ABSTRACT OBJECTIVES: Identifying individuals with vitamin B12 (B12) deficiency is challenging due to poor harmonization across total B12 assays. To establish clinically meaningful thresholds for the Roche assay, we characterized B12 concentrations associated with deficiency by comparing individuals with macrocytic anemia and … Read more

Analytical performance of the Roche Elecsys TnT hs Gen 6 immunoassayMarco Tosion February 16, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 17. doi: 10.1515/cclm-2026-0115. Online ahead of print. ABSTRACT OBJECTIVES: The acute coronary syndrome (ACS) is a leading cause of morbidity and mortality worldwide, with timely diagnosis being critical for improving outcomes. Since high-sensitivity cardiac troponin (hs-cTn) assays have become the gold standard for detecting myocardial injury, this study aimed … Read more

On the cusp of global lipoprotein(a) standardizationChrista M Cobbaerton February 16, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Feb 16. doi: 10.1515/cclm-2026-0149. Online ahead of print. ABSTRACT Lipoprotein(a) (Lp(a)) has the reputation of being the most misunderstood metric in laboratory medicine. The unique apolipoprotein(a) (apo(a)) in Lp(a) is very heterogenous, the kringle IV domain of apo(a) being formed by 12-50 kringles due to 3 to ∼40 KIV2 repeats. … Read more

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