Clinical Chemistry and Laboratory Medicine

Biomarkers in body fluids and their detection techniques for human intestinal permeability assessmentJian Zhangon August 12, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 13. doi: 10.1515/cclm-2025-0318. Online ahead of print. ABSTRACT INTRODUCTION: Intestinal permeability (IP) is a crucial index for intestinal tract integrity, reflecting intestinal barrier function, injury, diseases, and related systemic conditions. However, current mainstream testing methods are invasive and qualitative. Biomarkers for IP in body fluids offer noninvasive and quantitative … Read more

Overview of laboratory diagnostics for immediate management of patients presenting to the emergency department with acute bleedingGiuseppe Lippion August 12, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 13. doi: 10.1515/cclm-2025-0775. Online ahead of print. ABSTRACT Acute, life-threatening bleeding is a relatively common but critical presentation in the emergency department (ED), needing immediate assessment and intervention to reduce morbidity and mortality. Rapid identification of the bleeding source, evaluation of hemostatic function, and timely initiation of resuscitation are … Read more

Challenges of using natriuretic peptides to screen for the risk of developing heart failure in patients with diabetes: a report from the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Committee on Clinical Applications of Cardiac Bio-Markers (C-CB)Allan S Jaffeon August 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 12. doi: 10.1515/cclm-2025-0863. Online ahead of print. ABSTRACT BACKGROUND: Several guidelines groups have made recommendations about how to use natriuretic peptides (NPs) to screen patients with diabetes for incipient heart failure. This group is at risk for undetected and stage B heart failure, where structural heart disease is present … Read more

Supplementation of pyridoxal-5′-phosphate in aminotransferase reagents: a matter of patient safetyMauro Panteghinion August 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 12. doi: 10.1515/cclm-2025-0947. Online ahead of print. ABSTRACT As aminotransferases represent the first-level tests to detect individuals with hepatocellular damage, standardization of their measurements is a priority need for patient care. The obtaining of the harmonization in aminotransferase results is however strongly dependent on supplementation of pyridoxal-5′-phosphate (P-5-P) in … Read more

Reference ranges for ionized calcium in plasma in Danish children aged 0 days to 3 years using laboratory registry dataAnne-Sofie Allermann Faarvangon August 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 12. doi: 10.1515/cclm-2025-0353. Online ahead of print. ABSTRACT OBJECTIVES: Measurement of ionized calcium is frequently used in the assessment of calcium metabolism. However, the utility of ionized calcium in young children can pose a challenge. In this study, we aimed at establishing novel accurate reference ranges for ionized calcium … Read more

Assessment of measurement uncertainty of immunoassays and LC-MS/MS methods for serum 25-hydroxyvitamin DEtienne Cavalieron August 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 12. doi: 10.1515/cclm-2025-0554. Online ahead of print. ABSTRACT OBJECTIVES: Accurate 25-hydroxyvitamin D (25-(OH)D) assays are essential for defining vitamin D status and ensuring appropriate clinical decisions. Standardization efforts, including the Vitamin D Standardization Program (VDSP), aim to minimize assay variability. This study evaluates the measurement uncertainty (MU) of various … Read more

HCV serology: an unfinished agendaClaudio Gallion August 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 11. doi: 10.1515/cclm-2025-0501. Online ahead of print. ABSTRACT Over 50 years have elapsed since the clinical definition of non-A, non-B hepatitis and 36 years since the unveiling of hepatitis C virus (HCV) and the availability of specific serological assays, but few advances in the serological diagnosis of HCV infection … Read more

Oral salt loading combined with postural stimulation tests for confirming and subtyping primary aldosteronismJenny Yeuk Ki Chengon August 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0644. Online ahead of print. ABSTRACT OBJECTIVES: Primary aldosteronism (PA) is an underdiagnosed yet important condition. This study aimed to evaluate the diagnostic performance of a combined protocol using oral salt loading and postural stimulation tests (PST), named the balance study, to confirm and subtype PA. METHODS: … Read more

Clinical validation of a liquid chromatography single quadrupole mass spectrometry (LC-MS) method using Waters Kairos™ Amino Acid Kit reagentsRowan Hellieron August 8, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0424. Online ahead of print. ABSTRACT OBJECTIVES: Quantitation of plasma amino acids (AA) is critical for the diagnosis and monitoring of inherited disorders of AA metabolism. AA analysis using ion-exchange chromatography (IEC) with post-column ninhydrin derivatization is time consuming, with run times of ∼2 h, limiting sample … Read more

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