Clinical Chemistry and Laboratory Medicine

An isotope dilution-liquid chromatography tandem mass spectrometry-based candidate reference measurement procedure for the quantification of dehydroepiandrosterone in human serum and plasmaLea Lewinon January 21, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 22. doi: 10.1515/cclm-2025-1156. Online ahead of print. ABSTRACT OBJECTIVES: Dehydroepiandrosterone (DHEA) is a steroid prohormone and important precursor for estrogen and testosterone biosynthesis. For differential diagnosis of sexual development disorders (e.g., polycystic ovary syndrome, congenital adrenal hyperplasia), accurate measurement of DHEA in clinical testing is essential. To address that … Read more

Science, Quality and Value of Laboratory MedicineMario Plebanion January 21, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 22. doi: 10.1515/cclm-2026-0041. Online ahead of print. ABSTRACT The Meeting on Science, Quality and Value of Laboratory Medicine was held on 11 December 2025 in Padua, immediately preceding the 7th European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Conference on the Preanalytical Phase. For organizational reasons, the meeting … Read more

Assessment for potential bias in multiplexed IL-10 and TNF-α from plex countWade M Sanderson January 16, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 19. doi: 10.1515/cclm-2025-0458. Online ahead of print. ABSTRACT OBJECTIVES: Multiplex arrays offer a high-throughput, cost-effective means for quantifying multiple analytes simultaneously, essential for large-scale biomarker research. However, the shared reactive environment in multiplex assays could lead to variations in results compared to single plex assays, potentially impacting outcomes. This … Read more

Automation in value-based laboratory medicine: driving precision, capacity, and better outcomesDamien Grusonon January 13, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 15. doi: 10.1515/cclm-2026-0023. Online ahead of print. ABSTRACT Laboratory medicine lies at the core of modern healthcare, enabling timely diagnosis, effective patient monitoring, and increasingly personalized therapeutic strategies. Over the past decades, automation has profoundly reshaped the role of clinical laboratories, substantially enhancing their contribution to clinical outcomes, operational … Read more

One copy in one-pot for rapid and accurate SFTSV testing by LAC12b-2MYa Pangon January 13, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 14. doi: 10.1515/cclm-2025-0791. Online ahead of print. ABSTRACT OBJECTIVES: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne pathogen that can cause a fatality rate as high as 12-50 %, posing a significant threat to public health. SFTSV is prevalent in mountainous and hilly regions with relatively poor … Read more

Comparability, compatibility, equivalence and interchangeability: metrological concepts widely misunderstood in laboratory medicineRaúl Rigo-Bonninon January 9, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 12. doi: 10.1515/cclm-2025-1644. Online ahead of print. ABSTRACT BACKGROUND: Method-comparison studies in laboratory medicine are routinely interpreted using regression-based or Bland-Altman analyses. Although useful descriptively, these statistical procedures are frequently misapplied to infer “agreement”, “equivalence”, or “interchangeability”. Such interpretations overlook essential metrological conditions – including the definition of the … Read more

Multi-analytical identification of the synthetic opioids cychlorphine and methiodone (IC-26) in drug seizures: first detection in EuropePaméla Dugueson January 8, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 12. doi: 10.1515/cclm-2025-1428. Online ahead of print. ABSTRACT OBJECTIVES: The rapid emergence of highly potent synthetic opioids represents a growing challenge for forensic and clinical laboratories. METHODS: We report the first identification in Europe of methiodone (IC-26) and the first detection in France of cychlorphine in drug samples collected … Read more

Establishment of allowable total error for semen analysis based on the state of the art in ChinaYan Zhengon January 8, 2026 at 11:00 am

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Clin Chem Lab Med. 2026 Jan 9. doi: 10.1515/cclm-2025-1222. Online ahead of print. ABSTRACT OBJECTIVES: To establish evidence-based analytical performance specifications (APS), specifically allowable total error (TEa), for five fundamental semen analysis parameters (sperm concentration, progressive motility, total motility, morphology, and vitality) in China utilizing the state-of-the-art model, and to compare these specifications with existing … Read more

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