Clinical Chemistry and Laboratory Medicine

Evaluation of stability and potential interference on the α-thalassaemia early eluting peak and immunochromatographic strip test for α-thalassaemia –SEA carrier screeningWing Kit Lamon August 16, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 18. doi: 10.1515/cclm-2025-0754. Online ahead of print. ABSTRACT OBJECTIVES: α-Thalassaemia screening is crucial for identifying carriers at risk of having offspring with haemoglobin (Hb) Bart’s hydrops fetalis syndrome. This study evaluated the performance of two potential screening methods: the α-thalassaemia early eluting peak (αEEP) identified by high-performance liquid chromatography … Read more

The importance of laboratory medicine in the management of CKD-MBD: insights from the KDIGO 2023 controversies conferenceSamuel D Vasikaranon August 16, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 15. doi: 10.1515/cclm-2025-0802. Online ahead of print. ABSTRACT Laboratory investigations are important in the clinical management and the study of chronic kidney disease-mineral and bone disorder (CKD-MBD)- including CKD-associated osteoporosis. Parathyroid hormone (PTH) is the major hormone in the regulation of bone and calcium balance but is significantly affected … Read more

Analytical and clinical evaluation of an automated high-sensitivity cardiac troponin I assay for whole bloodJin-Xing Yuon August 14, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 15. doi: 10.1515/cclm-2025-0143. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate the performance of the iStar high-sensitivity cardiac troponin I (hs-cTnI) assay, focusing on its sensitivity, precision, linearity, and consistency with plasma samples, and to establish sex-specific 99th percentile upper reference limits. METHODS: The iStar hs-cTnI assay was assessed … Read more

From metabolic profiles to clinical interpretation: multivariate approaches to population-based and personalized reference intervals and reference change valuesAbdurrahman Coskunon August 14, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 15. doi: 10.1515/cclm-2025-0786. Online ahead of print. ABSTRACT Interpretation of laboratory test results is a comparative process that requires reference data. Such data are derived for each analyte separately, without accounting for, the interrelationships among analytes. Physicians use test panels containing multiple analytes to enhance clinical significance and improve … Read more

Comparative analysis of population-based and personalized reference intervals for biochemical markers in peri-menopausal women: population from the PALM cohort studyJiaming Wuon August 13, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 14. doi: 10.1515/cclm-2025-0658. Online ahead of print. ABSTRACT OBJECTIVES: Significant changes in clinical biochemical markers occur during the peri-menopausal period. Traditional population-based reference intervals (popRIs) may not reflect individual physiological variability, limiting clinical interpretation. This study aimed to establish personalized reference intervals (prRIs) for menopausal women and compare them … Read more

Evaluating large language models as clinical laboratory test recommenders in primary and emergency care: a crucial step in clinical decision makingAhmed Medhat Zayedon August 13, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 14. doi: 10.1515/cclm-2025-0647. Online ahead of print. ABSTRACT OBJECTIVES: Large language models (LLMs), such as OpenAI’s GPT-4o, have demonstrated considerable promise in transforming clinical decision support systems. In this study, we focused on a single but crucial task of clinical decision-making: laboratory test ordering. METHODS: We evaluated the self-consistency … Read more

The current status of serum insulin measurements and the need for standardizationCurt Rohlfingon August 13, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 14. doi: 10.1515/cclm-2025-0552. Online ahead of print. ABSTRACT OBJECTIVES: Insulin assays are used to assess insulin resistance and to aid in the diagnosis of conditions such as insulinoma and various forms of hypoglycemia. However, discrepancies among commercial assays limit their clinical and research utility. This study evaluates the current … Read more

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