Clinical Chemistry and Laboratory Medicine

A step forward in pediatric hemophagocytic lymphohistiocytosis and autoimmune disease: pediatric reference interval for serum soluble IL-2 receptor and soluble CD163Victor Bruunon July 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 25. doi: 10.1515/cclm-2025-0653. Online ahead of print. ABSTRACT OBJECTIVES: Hemophagocytic lymphohistiocytosis (HLH) is a severe condition requiring timely diagnosis to initiate immunomodulatory therapy. Soluble interleukin-2 receptor (sIL-2R) and soluble CD163 (sCD163) are biomarkers crucial for making this diagnosis. This study aims to establish pediatric reference intervals (RIs) for serum … Read more

Robustness of steroidomics-based machine learning for diagnosis of primary aldosteronism: a laboratory medicine perspectiveGraeme Eisenhoferon July 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 25. doi: 10.1515/cclm-2025-0200. Online ahead of print. ABSTRACT OBJECTIVES: Use of machine learning (ML) in diagnostics offers promise to optimise interpretation of laboratory data and guide clinical decision-making. For this, ML-based outputs should provide robustly reproducible results at least as good as the underlying laboratory data. The objective of … Read more

Can Theranos resurrect from its ashes?Miyo K Chatanakaon July 16, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 18. doi: 10.1515/cclm-2025-0651. Online ahead of print. ABSTRACT Theranos was a biotechnology company which, in the 2010s, promised to revolutionize traditional clinical chemistry testing by using novel technology, microvolumes of blood obtained by finger pricks, and performance of tests outside traditional clinical chemistry laboratories, such as in pharmacies. Theranos … Read more

MAGLUMI® Tacrolimus (CLIA) assay: analytical performances and comparison with LC-MS/MS and ARCHITECT Tacrolimus (CMIA) assayMingpeng Fuon July 15, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 16. doi: 10.1515/cclm-2025-0181. Online ahead of print. ABSTRACT OBJECTIVES: Tacrolimus has been a cornerstone of immunosuppressive therapy over the past two decades. Due to its narrow therapeutic window and pharmacokinetic variability, drug monitoring is vital for enhancing the efficacy and safety during therapy. In the present study, we evaluated … Read more

Utilization analysis of laboratory tests using health insurance claims data: advancing nationwide diagnostic stewardship monitoring systemsSe-Eun Kooon July 14, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 15. doi: 10.1515/cclm-2025-0641. Online ahead of print. ABSTRACT OBJECTIVES: Diagnostic stewardship aims to optimize laboratory testing practices by ensuring appropriate test utilization while minimizing unnecessary testing. However, the nationwide monitoring systems for laboratory test utilization remain underdeveloped. In this study, we analyzed nationwide health insurance claims data to identify … Read more

What matters most: an age-friendly approach to pathology and laboratory medicineMelody Boudreaux Nelsonon July 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 14. doi: 10.1515/cclm-2025-0616. Online ahead of print. ABSTRACT Under the Age-Friendly Health System initiative, “What Matters” is defined as knowing the older adult’s specific health outcome goals and care preferences. This involves multiple settings of care (e.g., hospital, skilled nursing facility, outpatient visits) and can include end-of-life care. However, … Read more

Assessment of 2023 ACR/EULAR antiphospholipid syndrome classification criteria in a Spanish cohortRodrigo Cantera Estefaníaon July 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 14. doi: 10.1515/cclm-2025-0508. Online ahead of print. ABSTRACT OBJECTIVES: The 2023 ACR/EULAR criteria aim to improve the classification of antiphospholipid syndrome (APS). This study aims to validate these criteria and compare clinical and laboratory domains between classified and non-classified patients. METHODS: A retrospective cohort study was conducted at the … Read more

Performance of afternoon (16:00 h) serum cortisol for the diagnosis of Cushing’s syndromeHippolyte Dupuison July 10, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 11. doi: 10.1515/cclm-2025-0133. Online ahead of print. ABSTRACT INTRODUCTION: Late-night salivary cortisol (LNSC), which assesses the loss of the circadian rhythm of cortisol, is one of the first-line tests performed to diagnose Cushing’s syndrome (CS). Unfortunately, access to LNSC is still limited in some institutions. Alternatively, midnight serum cortisol … Read more

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