Clinical Chemistry and Laboratory Medicine

Establishment of region-, age- and sex-specific reference intervals for aldosterone and renin with sandwich chemiluminescence immunoassaysLin-Lin Caoon August 7, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0587. Online ahead of print. ABSTRACT OBJECTIVES: Accurate measurement of plasma aldosterone (ALD) and renin is important in primary aldosteronism screening and diagnosis. The high variability of ALD and renin due to salt intake, age, and sex, as well as the lack of immunoassay standardization necessitates the … Read more

Investigation of the possible cause of over-estimation of human aldosterone in plasma, using a unique, non-synthetic human aldosterone-free matrixSheree Stoneron July 31, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Aug 1. doi: 10.1515/cclm-2024-1468. Online ahead of print. ABSTRACT OBJECTIVES: Aldosterone is over-estimated by direct immunoassay when compared to assay by LC-MS/MS. We have investigated the mechanism for this over-estimation, using dichloromethane (DCM) extraction and a unique matrix of non-synthetic aldosterone-free plasma (ALFP). METHODS: Samples used were from patients with … Read more

A step forward in pediatric hemophagocytic lymphohistiocytosis and autoimmune disease: pediatric reference interval for serum soluble IL-2 receptor and soluble CD163Victor Bruunon July 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 25. doi: 10.1515/cclm-2025-0653. Online ahead of print. ABSTRACT OBJECTIVES: Hemophagocytic lymphohistiocytosis (HLH) is a severe condition requiring timely diagnosis to initiate immunomodulatory therapy. Soluble interleukin-2 receptor (sIL-2R) and soluble CD163 (sCD163) are biomarkers crucial for making this diagnosis. This study aims to establish pediatric reference intervals (RIs) for serum … Read more

Robustness of steroidomics-based machine learning for diagnosis of primary aldosteronism: a laboratory medicine perspectiveGraeme Eisenhoferon July 24, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 25. doi: 10.1515/cclm-2025-0200. Online ahead of print. ABSTRACT OBJECTIVES: Use of machine learning (ML) in diagnostics offers promise to optimise interpretation of laboratory data and guide clinical decision-making. For this, ML-based outputs should provide robustly reproducible results at least as good as the underlying laboratory data. The objective of … Read more

Can Theranos resurrect from its ashes?Miyo K Chatanakaon July 16, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jul 18. doi: 10.1515/cclm-2025-0651. Online ahead of print. ABSTRACT Theranos was a biotechnology company which, in the 2010s, promised to revolutionize traditional clinical chemistry testing by using novel technology, microvolumes of blood obtained by finger pricks, and performance of tests outside traditional clinical chemistry laboratories, such as in pharmacies. Theranos … Read more

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