Clinical Chemistry and Laboratory Medicine

Clin Chem Lab Med. 2025 Aug 12. doi: 10.1515/cclm-2025-0863. Online ahead of print. ABSTRACT BACKGROUND: Several guidelines groups have made recommendations about how to use natriuretic peptides (NPs) to screen patients with diabetes for incipient heart failure. This group is at risk for undetected and stage B heart failure, where structural heart disease is present … Read more

Clin Chem Lab Med. 2025 Aug 12. doi: 10.1515/cclm-2025-0947. Online ahead of print. ABSTRACT As aminotransferases represent the first-level tests to detect individuals with hepatocellular damage, standardization of their measurements is a priority need for patient care. The obtaining of the harmonization in aminotransferase results is however strongly dependent on supplementation of pyridoxal-5′-phosphate (P-5-P) in … Read more

Clin Chem Lab Med. 2025 Aug 12. doi: 10.1515/cclm-2025-0353. Online ahead of print. ABSTRACT OBJECTIVES: Measurement of ionized calcium is frequently used in the assessment of calcium metabolism. However, the utility of ionized calcium in young children can pose a challenge. In this study, we aimed at establishing novel accurate reference ranges for ionized calcium … Read more

Clin Chem Lab Med. 2025 Aug 12. doi: 10.1515/cclm-2025-0554. Online ahead of print. ABSTRACT OBJECTIVES: Accurate 25-hydroxyvitamin D (25-(OH)D) assays are essential for defining vitamin D status and ensuring appropriate clinical decisions. Standardization efforts, including the Vitamin D Standardization Program (VDSP), aim to minimize assay variability. This study evaluates the measurement uncertainty (MU) of various … Read more

Clin Chem Lab Med. 2025 Aug 11. doi: 10.1515/cclm-2025-0501. Online ahead of print. ABSTRACT Over 50 years have elapsed since the clinical definition of non-A, non-B hepatitis and 36 years since the unveiling of hepatitis C virus (HCV) and the availability of specific serological assays, but few advances in the serological diagnosis of HCV infection … Read more

Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0644. Online ahead of print. ABSTRACT OBJECTIVES: Primary aldosteronism (PA) is an underdiagnosed yet important condition. This study aimed to evaluate the diagnostic performance of a combined protocol using oral salt loading and postural stimulation tests (PST), named the balance study, to confirm and subtype PA. METHODS: … Read more

Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0424. Online ahead of print. ABSTRACT OBJECTIVES: Quantitation of plasma amino acids (AA) is critical for the diagnosis and monitoring of inherited disorders of AA metabolism. AA analysis using ion-exchange chromatography (IEC) with post-column ninhydrin derivatization is time consuming, with run times of ∼2 h, limiting sample … Read more

Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0330. Online ahead of print. ABSTRACT OBJECTIVES: Haemolysis is a major preanalytical issue that affects potassium measurements, often leading to sample rejection and delayed clinical management. This study proposes a novel corrective model for accurate unhaemolysed potassium prediction. METHODS: Blood samples from 14 healthy volunteers were used … Read more

Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0855. Online ahead of print. ABSTRACT Since the 1980s, automation has profoundly transformed clinical laboratory operations, enhancing efficiency, standardization, and throughput. This technological evolution has enabled laboratories to meet rising testing demands, address persistent workforce shortages, and control operational costs. Beyond analytical consolidation, significant progress has been … Read more

Clin Chem Lab Med. 2025 Aug 8. doi: 10.1515/cclm-2025-0587. Online ahead of print. ABSTRACT OBJECTIVES: Accurate measurement of plasma aldosterone (ALD) and renin is important in primary aldosteronism screening and diagnosis. The high variability of ALD and renin due to salt intake, age, and sex, as well as the lack of immunoassay standardization necessitates the … Read more