Clinical Chemistry and Laboratory Medicine

Digital metrology in laboratory medicine: a call for bringing order to chaos to facilitate precision diagnosticsMadeleen Bosmaon April 14, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 16. doi: 10.1515/cclm-2025-0152. Online ahead of print. ABSTRACT Laboratory medicine is faced with rapid developments in data exchange, secondary use of data and artificial intelligence. Safe exchange of laboratory data requires a suitable terminology standard. NPU, LOINC and SNOMED CT are increasingly used for this purpose, but none of … Read more

Assessment of serum free light chain measurements in a large Chinese chronic kidney disease cohort: a multicenter real-world studyXia Luoon April 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 14. doi: 10.1515/cclm-2024-1226. Online ahead of print. ABSTRACT OBJECTIVES: Diagnosing monoclonal gammopathy in chronic kidney disease (CKD) patients is challenging due to the complex interpretation of serum free light chain (FLC) levels. This study aimed to assess the FLC levels in a large cohort of Chinese CKD patients. METHODS: … Read more

Defining dried blood spot diameter: implications for measurement and specimen rejection ratesNick Flynnon April 11, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 14. doi: 10.1515/cclm-2025-0183. Online ahead of print. ABSTRACT OBJECTIVES: Dried blood spot (DBS) specimen acceptance guidelines recommend rejecting specimens based on DBS size, often expressed as a diameter. Computer vision methods can estimate DBS size from images obtained from standalone equipment, smartphone cameras or existing laboratory instrumentation. However, no … Read more

Clostebol detection after transdermal and transmucosal contact. A systematic reviewVincenzo Giannicola Mendittoon April 10, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 11. doi: 10.1515/cclm-2025-0331. Online ahead of print. ABSTRACT INTRODUCTION: To analyze the available evidence about the correlation between the presence of detectable amounts of clostebol metabolites in urine and the transdermal or transmucosal contact of clostebol. CONTENT: A systematic review was performed. A systematic search was conducted in PubMed/MEDLINE, … Read more

Supporting prioritization efforts of higher-order reference providers using evidence from the Joint Committee for Traceability in Laboratory Medicine databaseMauro Panteghinion April 10, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 11. doi: 10.1515/cclm-2025-0401. Online ahead of print. ABSTRACT The Joint Committee for Traceability in Laboratory Medicine (JCTLM) database represents a valuable resource for implementing metrological traceability in laboratory medicine. Three main database users can be identified: (a) in vitro diagnostic (IVD) manufacturers, using the database information for meeting ISO … Read more

Cell population data for early detection of sepsis in patients with suspected infection in the emergency departmentMarta Cancella De Abreuon April 10, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 11. doi: 10.1515/cclm-2025-0180. Online ahead of print. ABSTRACT OBJECTIVES: Traditional biomarkers used for sepsis diagnosis have limited sensitivity and specificity and, so far, are not recommended for sepsis diagnosis. We aimed to evaluate diagnostic accuracy of XN-9000® hematology analyzer derived cell population data (CPD) for sepsis. METHODS: We conducted … Read more

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