Clinical Chemistry and Laboratory Medicine

New insights in preanalytical qualityMario Plebanion April 23, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 24. doi: 10.1515/cclm-2025-0478. Online ahead of print. ABSTRACT The negative impact of preanalytical errors on the quality of laboratory testing is now universally recognized. Nonetheless, recent technological advancements and organizational transformations in healthcare – catalyzed by the still ongoing coronavirus disease 2019 (COVID-19 pandemic) – have introduced new challenges … Read more

Impact of renal function impairment on kappa free light chain indexMartin Schmidaueron April 19, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0007. Online ahead of print. ABSTRACT OBJECTIVES: To investigate whether renal function impacts CSF κ-FLC concentration and/or κ-FLC index. METHODS: Patients with non-inflammatory neurological diseases were eligible. κ-FLC index was calculated as (CSF κ-FLC/serum κ-FLC)/albumin quotient. Structural equation modeling (SEM) was used to evaluate the direct influence … Read more

Evaluation of error detection and treatment recommendations in nucleic acid test reports using ChatGPT modelsWenzheng Hanon April 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0089. Online ahead of print. ABSTRACT OBJECTIVES: Accurate medical laboratory reports are essential for delivering high-quality healthcare. Recently, advanced artificial intelligence models, such as those in the ChatGPT series, have shown considerable promise in this domain. This study assessed the performance of specific GPT models-namely, 4o, o1, … Read more

The accuracy of presepsin in diagnosing neonatal late-onset sepsis in critically ill neonates: a prospective studyCinzia Aurition April 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 21. doi: 10.1515/cclm-2025-0128. Online ahead of print. ABSTRACT OBJECTIVES: The diagnostic accuracy of presepsin (P-SEP) in the newborn is still under evaluation. METHODS: In a multicenter study, we studied the accuracy of P-SEP as a diagnostic marker of late-onset sepsis (LOS) in critical newborns with underlying disorders, to define … Read more

Direct screening and quantification of monoclonal immunoglobulins in serum using MALDI-TOF mass spectrometry without antibody enrichmentHou-Long Luoon April 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 18. doi: 10.1515/cclm-2025-0203. Online ahead of print. ABSTRACT OBJECTIVES: Monoclonal gammopathies (MGs) are characterized by the presence of monoclonal immunoglobulins (M-proteins). Currently, recommendations for screening of MGs primarily rely on nephelometry, turbidimetry and electrophoresis, which have inherent limitations in sensitivity and throughput. This study aimed to evaluate a novel … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of cortisone in human serum and plasmaMyriam Otton April 16, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 17. doi: 10.1515/cclm-2024-1478. Online ahead of print. ABSTRACT OBJECTIVES: Cortisone is an inert precursor/metabolite of the potent steroid hormone cortisol. Measurement of serum cortisone levels and the cortisol-cortisone ratio can be useful for the diagnosis of dysfunction in the regulation of cortisol levels (i.e., severe and subtle apparent mineralocorticoid … Read more

Evaluation of sex-specific 0-h high-sensitivity cardiac troponin T thresholds for the risk stratification of non-ST-segment elevation myocardial infarctionAilun Zhangon April 16, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Apr 17. doi: 10.1515/cclm-2024-1118. Online ahead of print. ABSTRACT OBJECTIVES: We aimed to evaluate sex-specific 0-h high-sensitivity cardiac troponin T (hs-cTnT) thresholds for risk stratification in patients with suspected non-ST-segment elevation myocardial infarction (NSTEMI). METHODS: This retrospective study investigated a derivation cohort of 6,691 (44.4 % female and aged 65 … Read more

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