Clinical Chemistry and Laboratory Medicine

Clinical validation of a DBS-based LC-MS/MS method for 25-hydroxyvitamin D: from lab sampling to home samplingLiesl Heughebaerton November 12, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 13. doi: 10.1515/cclm-2025-1002. Online ahead of print. ABSTRACT OBJECTIVES: As (a lack of) vitamin D has been linked to a wide variety of chronic diseases, there is growing interest in generating robust epidemiological data. Consequently, the need for large-scale biological sample collection has increased. In this context, dried blood … Read more

Prognostic utility of serial procalcitonin measurements in ICU sepsis: a laboratory-led modelling approach in a resource-limited setting procalcitonin modelling for sepsis mortality in a low-resource ICUAaqilah Fataaron November 11, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 12. doi: 10.1515/cclm-2025-0778. Online ahead of print. ABSTRACT OBJECTIVES: Procalcitonin (PCT) is increasingly used to support sepsis diagnosis, but its role in predicting outcomes remains uncertain, particularly in low-resource settings. We evaluated whether single and serial PCT measurements were associated with 28-day mortality in critically ill adults with suspected … Read more

VeRUS: verification of reference intervals based on the uncertainty of samplingMatthias Beckon November 10, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 11. doi: 10.1515/cclm-2025-0728. Online ahead of print. ABSTRACT OBJECTIVES: Laboratories are required to routinely verify reported reference intervals (RIs), but common verification methods like the CLSI-EP28-A3c binomial test are often impractical due to sample collection requirements. Indirect verification methods like equivalence limits (ELs) use routine data from patient care … Read more

Comparison of the cardiac troponin I-cardiac troponin T-troponin C complex and cardiac troponin I and T in distinguishing myocardial infarction using a single sample at presentationLing Lion November 10, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 11. doi: 10.1515/cclm-2025-0385. Online ahead of print. ABSTRACT OBJECTIVES: The potential relationship between cardiac troponin (cTn) composition and etiologies of myocardial injury may provide diagnostic insights for myocardial infarction (MI). We compared the performance of novel ternary cTnI-cTnT-TnC complex (ITC) assays with high-sensitivity (hs)-cTnI and hs-cTnT in differentiating MI … Read more

Thresholds adjustments and impact on clinical performance of three FIT assays in a colorectal cancer screening programJean Dubéon November 9, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-0546. Online ahead of print. ABSTRACT OBJECTIVES: Fecal immunochemical tests (FITs) from various manufacturers yield different results, leading to variable positivity rates and clinical performance. These differences can influence the healthcare costs of a colorectal cancer screening program (CRC-SP), specifically when switching among FIT manufacturers. The analytical … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of mycophenolic acid glucuronide in human serum and plasmaTobias Schierscheron November 7, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-1052. Online ahead of print. ABSTRACT OBJECTIVES: A candidate reference measurement procedure (RMP) based on isotope dilution (ID) liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated to accurately measure serum and plasma concentrations of mycophenolic acid glucuronide (MPAG). METHODS: Quantitative nuclear magnetic resonance (qNMR) spectroscopy was … Read more

Pro-gastrin releasing peptide as a tumor marker of medullary thyroid carcinoma: a comparative bivariate meta-analysisPetra Petranović Ovčaričekon November 7, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 10. doi: 10.1515/cclm-2025-0867. Online ahead of print. ABSTRACT OBJECTIVES: Calcitonin (CT) is the established biomarker for medullary thyroid carcinoma (MTC), but its measurement is hampered by analytical limitations. Procalcitonin (PCT) and pro-gastrin-releasing peptide (ProGRP) have been proposed as alternative or complementary markers, yet the diagnostic value of ProGRP remains … Read more

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