Clinical Chemistry and Laboratory Medicine

Health-related reference intervals for heavy metals in non-exposed young adultsChiara Di Restaon June 14, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 16. doi: 10.1515/cclm-2025-0076. Online ahead of print. ABSTRACT OBJECTIVES: Heavy Metals (HMs) concentrations vary with living environments, diet, and personal habits. This study aims to establish health-related reference intervals (RIs) for selected HMs in healthy, non-occupationally exposed young adults living in an urban environment. METHODS: The Uni4Me study enrolled … Read more

Australasian guideline for the performance of sweat chloride testing 3rd edition: to support cystic fibrosis screening, diagnosis and monitoringJohn Massieon June 6, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 9. doi: 10.1515/cclm-2025-0433. Online ahead of print. ABSTRACT The sweat test is used as a biological marker of cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction, but there is growing recognition that sweat chloride concentrations of people with cystic fibrosis (CF) can overlap with those without CF. There are also … Read more

A comparison of current methods to measure antibodies in type 1 diabetesMaria Infantinoon June 3, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 4. doi: 10.1515/cclm-2025-0238. Online ahead of print. ABSTRACT OBJECTIVES: Type 1 diabetes (T1D) is a chronic autoimmune disease causing β-cell destruction, hyperglycemia, and lifelong insulin dependence that can lead to severe complications like ketoacidosis, with a 1 % mortality rate in newly diagnosed patients. A significant breakthrough in T1D … Read more

Validation of (self-collected) capillary blood using a topper collection system as alternative for venous sampling for 15 common clinical chemistry analytesRümeysa Geujaron June 3, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 2. doi: 10.1515/cclm-2025-0148. Online ahead of print. ABSTRACT OBJECTIVES: Home blood sampling for clinical purposes has gained much interest. This study validates the recently developed Topper-based capillary blood collection procedure for 15 commonly used chemistry analytes. METHODS: A total of 120 study participants (21 healthy volunteers and 99 patients) … Read more

No fault or negligence after an adverse analytical finding due to a contaminated supplement: mission impossible. Two examples involving trimetazidinePascal Kintzon June 3, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 30. doi: 10.1515/cclm-2025-0549. Online ahead of print. ABSTRACT Since several years, sports authorities, including national anti-doping organisations and the World Anti-Doping Agency (WADA) have published that the consumption of food supplements can be at risk for athletes due to potential contamination by prohibited substances. Despite these warnings, supplements are … Read more

Immunochemical measurement of urinary free light chains and Bence Jones proteinuriaLaura Michettion June 3, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 30. doi: 10.1515/cclm-2025-0265. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate the characteristics of an immunochemical urinary free light chains (uFLC) test in screening and quantifying Bence Jones proteinuria (BJP) and its potential application in laboratory practice as an alternative to the gold standard method, urine immunofixation (UIFE) and … Read more

Machine learning algorithms with body fluid parameters: an interpretable framework for malignant cell screening in cerebrospinal fluidXianfei Yeon May 29, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 May 28. doi: 10.1515/cclm-2025-0302. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to develop and validate a machine learning (ML) model utilizing cerebrospinal fluid (CSF) body fluid parameters from hematology analyzers to screen for malignant cells. METHODS: We analyzed 643 consecutive CSF samples from patients with central nervous system … Read more

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