Clinical Chemistry and Laboratory Medicine

Measuring neurofilament light in human plasma and cerebrospinal fluid: a comparison of five analytical immunoassaysUdit Shethon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 8. doi: 10.1515/cclm-2025-0610. Online ahead of print. ABSTRACT OBJECTIVES: Neurofilament light (NfL) is an established biofluid marker of neuroaxonal injury for neurological diseases. Several high-throughput and sensitive immunoassays have been developed to quantify NfL in blood and cerebrospinal fluid (CSF), facilitating the use of NfL as a biomarker in … Read more

Analysis of total cholesterol results measured in the initial period of the Croatian screening program for familial hypercholesterolemia: a pilot studyGordana Juričićon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 8. doi: 10.1515/cclm-2025-0536. Online ahead of print. ABSTRACT OBJECTIVES: In 2023, Croatia implemented a screening program for familial hypercholesterolemia (FH) targeting children entering the first grade of primary school. The program is based on total cholesterol (TC) concentration measurements. This pilot study aimed to assess and compare TC results … Read more

Performance evaluation of quantitative hemoglobin A2 and fetal hemoglobin testing using commercially lyophilized vs. in-house whole blood controls in Chinese clinical laboratories: a 12-year analysis of National External Quality Assessment DataYating Maon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 8. doi: 10.1515/cclm-2025-0683. Online ahead of print. ABSTRACT OBJECTIVES: To analyze the performance of laboratories in the China National External Quality Assessment Scheme (China NEQAS) for HbA2 and HbF testing, and to propose strategies for quality improvement. METHODS: Data were obtained from China NEQAS from 2013 to 2024 using … Read more

An assessment of molecular diagnosis of tuberculosis and multi-drug resistant tuberculosis testing and quality assessment: findings of an international surveyJim F Huggetton September 16, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 5. doi: 10.1515/cclm-2025-0750. Online ahead of print. ABSTRACT Molecular ‘in vitro diagnostic’ (IVD) tests are established for the diagnosis of tuberculosis (TB) and multi-drug resistant TB (MDR-TB). What is less clear is how the use of TB or MDR-TB molecular IVD results differ across regions, whether corroborative tests are … Read more

Not all anti-parietal cell antibody tests are equal for diagnosing pernicious anemiaValentin Lacombeon September 16, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 5. doi: 10.1515/cclm-2025-0671. Online ahead of print. ABSTRACT OBJECTIVES: Pernicious anemia (PA) is a common cause of vitamin B12 deficiency and requires a robust diagnosis to guide lifelong treatment. Anti-parietal cell antibodies (APCA) are frequently used as a diagnostic marker, but their poor specificity raises concerns about overdiagnosis, particularly … Read more

Defining the analytical characteristics of a novel high-sensitivity point-of-care troponin I assay in its intended clinical environmentJames Hatherleyon September 2, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 3. doi: 10.1515/cclm-2025-0374. Online ahead of print. ABSTRACT OBJECTIVES: To assess the imprecision and stability of the point-of-care troponin I assay in the Emergency Department and its correlation and bias to two central laboratory troponin I assays (Siemens Atellica and Abbott Alinity). METHODS: Imprecision and stability testing was performed … Read more

Method comparison of plasma and CSF GFAP immunoassays across multiple platformsBurak Arslanon September 1, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 2. doi: 10.1515/cclm-2025-0667. Online ahead of print. ABSTRACT OBJECTIVES: Glial fibrillary acidic protein (GFAP) is a biomarker of astrocytic activation associated with neurodegenerative diseases, neuroinflammatory disorders, and traumatic brain injury. However, the lack of standardized methods for quantifying GFAP across different immunoassay platforms poses challenges for its clinical implementation. … Read more

Interference of therapeutic monoclonal antibodies with electrophoresis and immunofixation of serum proteins: state of knowledge and systematic reviewSacha Pelletieron August 30, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 1. doi: 10.1515/cclm-2025-0678. Online ahead of print. ABSTRACT INTRODUCTION: The increasing use of therapeutic monoclonal antibodies (t-mAbs) has improved cancer and autoimmune disorder treatment. These therapeutics can interfere with serum protein electrophoresis (SPEP) and immunofixation (IF), potentially leading to the appearance of monoclonal bands that may be misinterpreted as … Read more

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