Clinical Chemistry and Laboratory Medicine

Artificial intelligence and machine learning in thrombosis and hemostasis: a scoping review of clinical and laboratory applications, challenges, and future directionsMohammad A Altememion December 16, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 17. doi: 10.1515/cclm-2025-1450. Online ahead of print. ABSTRACT This scoping review followed the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines to systematically map the current landscape of artificial intelligence (AI) and machine learning (ML) applications in the field of thrombosis and hemostasis … Read more

Quantitative analysis of phylloquinone (vitamin K1) and menaquinone (vitamin K2) in serum of Russians by liquid chromatography-tandem mass spectrometryMikhail Vokuevon December 15, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 16. doi: 10.1515/cclm-2025-0719. Online ahead of print. ABSTRACT OBJECTIVES: Vitamin K homologues are essential to human health, and their concentrations in biological samples serve as valuable diagnostic biomarkers. This study was aimed to develop a method for determining vitamins K1 (phylloquinone, VK1) and K2 (menaquinone, MK-4) in human serum. … Read more

The democratization of cancer screening, or a waste of valuable resources?Miyo K Chatanakaon December 12, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 15. doi: 10.1515/cclm-2025-1434. Online ahead of print. ABSTRACT The discovery of circulating tumor DNA (ctDNA) prompted many scientists and companies to apply this new technology for cancer diagnostics. One valuable application of ctDNA is in the screening for cancer. This procedure has been coined “liquid biopsy” and unlike classical … Read more

Prognostic value of suPAR in sepsis: a potential tool to support patient management in the Emergency DepartmentSimone Leggerion December 11, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 15. doi: 10.1515/cclm-2025-1299. Online ahead of print. ABSTRACT OBJECTIVES: The soluble urokinase plasminogen activator receptor (suPAR) is a well-established biomarker of immune activation, reflecting the severity of systemic inflammation. Recent evidence showed increasing interest in suPAR as a prognostic marker, with elevated levels consistently associated with greater disease severity … Read more

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