Clinical Chemistry and Laboratory Medicine

Isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedures for the quantification of total and free phenytoin in human serum and plasmaTobias Schierscheron June 21, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 23. doi: 10.1515/cclm-2024-0858. Online ahead of print. ABSTRACT OBJECTIVES: An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) was developed and validated to accurately measure serum and plasma concentrations of total and free phenytoin. METHODS: Quantitative nuclear magnetic resonance spectroscopy (qNMR) was used to determine the … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry based candidate reference measurement procedure for the simultaneous quantification of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 in human serum and plasmaKerstin Kandleron June 20, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 20. doi: 10.1515/cclm-2024-1138. Online ahead of print. ABSTRACT OBJECTIVES: An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for the quantification of 25-hydroxyvitamin D2 (25OHD2) and 25-hydroxyvitamin D3 (25OHD3) in human serum and plasma is presented. METHODS: Quantitative Nuclear Magnetic Resonance (qNMR) spectroscopic methodology has been … Read more

Assessment of atypical cells in detecting bladder cancer in female patientsYan Zhaoon June 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 18. doi: 10.1515/cclm-2025-0268. Online ahead of print. ABSTRACT OBJECTIVES: Atypical or malignant urothelial cells may be identified with a research parameter of atypical cells (Atyp.C) using a fully automated urine particle analyzer in routine urinalysis. This study aimed to determine whether Atyp.C can serve as an effective screening tool … Read more

The spectrum of nuclear patterns with stained metaphase chromosome plate: morphology nuances, immunological associations, and clinical relevanceWilson de Melo Cruvinelon June 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 18. doi: 10.1515/cclm-2025-0286. Online ahead of print. ABSTRACT The indirect immunofluorescence assay (IFA) on HEp-2 cells is the prevailing method used to screen for autoantibodies in the investigation of systemic autoimmune diseases (SAID). When positive, the titer provides a semi-quantitative assessment of the autoantibody serum concentration whereas the immunofluorescence … Read more

Health-related reference intervals for heavy metals in non-exposed young adultsChiara Di Restaon June 14, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 16. doi: 10.1515/cclm-2025-0076. Online ahead of print. ABSTRACT OBJECTIVES: Heavy Metals (HMs) concentrations vary with living environments, diet, and personal habits. This study aims to establish health-related reference intervals (RIs) for selected HMs in healthy, non-occupationally exposed young adults living in an urban environment. METHODS: The Uni4Me study enrolled … Read more

Australasian guideline for the performance of sweat chloride testing 3rd edition: to support cystic fibrosis screening, diagnosis and monitoringJohn Massieon June 6, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 9. doi: 10.1515/cclm-2025-0433. Online ahead of print. ABSTRACT The sweat test is used as a biological marker of cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction, but there is growing recognition that sweat chloride concentrations of people with cystic fibrosis (CF) can overlap with those without CF. There are also … Read more

A comparison of current methods to measure antibodies in type 1 diabetesMaria Infantinoon June 3, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 4. doi: 10.1515/cclm-2025-0238. Online ahead of print. ABSTRACT OBJECTIVES: Type 1 diabetes (T1D) is a chronic autoimmune disease causing β-cell destruction, hyperglycemia, and lifelong insulin dependence that can lead to severe complications like ketoacidosis, with a 1 % mortality rate in newly diagnosed patients. A significant breakthrough in T1D … Read more

Validation of (self-collected) capillary blood using a topper collection system as alternative for venous sampling for 15 common clinical chemistry analytesRümeysa Geujaron June 3, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Jun 2. doi: 10.1515/cclm-2025-0148. Online ahead of print. ABSTRACT OBJECTIVES: Home blood sampling for clinical purposes has gained much interest. This study validates the recently developed Topper-based capillary blood collection procedure for 15 commonly used chemistry analytes. METHODS: A total of 120 study participants (21 healthy volunteers and 99 patients) … Read more

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