Clinical Chemistry and Laboratory Medicine

EFLM checklist for the assessment of AI/ML studies in laboratory medicine: enhancing general medical AI frameworks for laboratory-specific applicationsAnna Carobeneon September 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 15. doi: 10.1515/cclm-2025-0841. Online ahead of print. ABSTRACT The integration of artificial intelligence (AI) and machine learning (ML) into laboratory medicine shows promise for advancing diagnostic, prognostic, and decision-support tools; however, routine clinical implementation remains limited and heterogeneous. Laboratory data presents unique methodological and semantic complexities – method dependency, … Read more

Predictive genomic medicine enlarges the spectrum of predisposing mutations for head and neck cancers via a panel of 56 genes selected for human neoplasia in Southern Italy: a pilot studyFederica Di Maggioon September 18, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 12. doi: 10.1515/cclm-2025-1159. Online ahead of print. ABSTRACT OBJECTIVES: Oral squamous cell carcinoma (OSCC) is the most prevalent form of squamous cell carcinomas of the head and neck (SCCHN), accounting for over 90 % of all oral cavity malignancies (approximately 275,000 new cases are worldwide diagnosed annually). Early-stage oral … Read more

Impact of renal and hepatic function on dihydropyrimidine dehydrogenase phenotype assessed by enzyme activity in peripheral blood mononuclear cells and uracilemiaSara Contuon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 10. doi: 10.1515/cclm-2025-0949. Online ahead of print. ABSTRACT OBJECTIVES: To investigate the relationship between uracilemia (U) and dihydropyrimidine dehydrogenase (DPD) activity in peripheral blood mononuclear cells (PBMC) and whether they are influenced by renal or hepatic impairment. METHODS: This retrospective study included 176 cancer patients with pre-treatment U (UPLC-MSMS … Read more

Value is equal to outcome/costs: how to apply to laboratory medicineRossella Tomaiuoloon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 10. doi: 10.1515/cclm-2025-0691. Online ahead of print. ABSTRACT The concept of value, defined as health outcomes achieved per monetary unit spent, has profoundly reshaped modern healthcare delivery. While Value-Based Healthcare models have permeated many clinical disciplines, laboratory medicine has been slow to integrate this paradigm shift. In this opinion … Read more

Comparison of seven different enzymatic methods for serum glycated albumin in pregnant women: a multicenter studyDandan Sunon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 10. doi: 10.1515/cclm-2025-0530. Online ahead of print. ABSTRACT OBJECTIVES: To evaluate the consistency of seven enzymatic glycated albumin (GA) assays in pregnant women based on a multicenter study. METHODS: Samples were collected from pregnant women at three different gestational stages: 4-13 weeks (n=150), 24-28 weeks (n=300, including 150 GDM … Read more

Proadrenomedullin for prediction of early and mid-term mortality in patients hospitalized for community-acquired pneumoniaAmaia Artarazon September 17, 2025 at 10:00 am

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Clin Chem Lab Med. 2025 Sep 8. doi: 10.1515/cclm-2025-0481. Online ahead of print. ABSTRACT OBJECTIVES: Our study sought to determine the usefulness of biomarkers of systemic inflammation (C-reactive protein (CRP), procalcitonin (PCT) and proadrenomedullin (proADM)) on hospital admission, as compared to the CURB65 score, for predicting 30- and 90-day mortality in patients hospitalized for community … Read more

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