Clinical Chemistry and Laboratory Medicine

Prognostic value of suPAR in sepsis: a potential tool to support patient management in the Emergency DepartmentSimone Leggerion December 11, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 15. doi: 10.1515/cclm-2025-1299. Online ahead of print. ABSTRACT OBJECTIVES: The soluble urokinase plasminogen activator receptor (suPAR) is a well-established biomarker of immune activation, reflecting the severity of systemic inflammation. Recent evidence showed increasing interest in suPAR as a prognostic marker, with elevated levels consistently associated with greater disease severity … Read more

Impact of an autonomous delivery robot on sample turnaround time in a clinical laboratory: an early evaluation of first implementationJacopo Gervasonion December 9, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 10. doi: 10.1515/cclm-2025-1336. Online ahead of print. ABSTRACT OBJECTIVES: The aim of this study was to evaluate the impact of introducing an autonomous courier in a clinical laboratory, focusing on specimen turnaround time (TAT). We assessed whether high-frequency robotic transport from the central accessioning area to analytical sections could … Read more

A specific-neonatal hemolysis correction model for accurate potassium assessment in blood samples with in vitro hemolysisJinmei Lion December 9, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 10. doi: 10.1515/cclm-2025-1484. Online ahead of print. ABSTRACT OBJECTIVES: Accurate determination of blood potassium levels in neonates presents significant clinical challenges, primarily attributable to technical difficulties in phlebotomy procedures and the elevated susceptibility of neonatal blood samples to hemolysis. This study aimed to develop and validate a hemoglobin-based mathematical … Read more

Extended verification of an automated MALDI-TOF mass spectrometry system for high throughput serum M-protein measurementLouis Nevejanon December 2, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 3. doi: 10.1515/cclm-2025-0894. Online ahead of print. ABSTRACT OBJECTIVES: This study aimed to perform an extended analytical verification of the Immunoglobulin Isotypes (GAM) for the EXENT® Analyzer (EXENT®-GAM) assay, a MALDI-TOF mass spectrometry-based method for detecting and quantifying serum M-proteins in patients with plasma cell dyscrasias, and to compare … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of progesterone in human serum and plasmaSara Cheikh Ibrahimon December 1, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 1. doi: 10.1515/cclm-2025-0514. Online ahead of print. ABSTRACT OBJECTIVES: Progesterone regulates reproductive processes and is used clinically to monitor ovarian function in people experiencing fertility problems. Measuring serum progesterone is challenging as it is highly protein-bound and exists at very low physiological levels. An isotope dilution-liquid chromatography-tandem mass spectrometry-based … Read more

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of dehydroepiandrosterone sulfate in human serum and plasmaSara Cheikh Ibrahimon November 29, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Dec 1. doi: 10.1515/cclm-2025-0179. Online ahead of print. ABSTRACT OBJECTIVES: Dehydroepiandrosterone sulfate (DHEAS), the sulfate ester of dehydroepiandrosterone, is one of the most common steroid hormones in the human body and the precursor of several other androgens. It is primarily used as a diagnostic or prognostic indicator in adrenal and … Read more

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