Clinical Chemistry and Laboratory Medicine

Clin Chem Lab Med. 2026 Mar 13. doi: 10.1515/cclm-2026-0323. Online ahead of print. ABSTRACT The Joint Committee for Traceability in Laboratory Medicine (JCTLM) supports worldwide equivalence and comparability of measurement results in laboratory medicine to improve health care and facilitate national and international trade in in vitro diagnostic (IVD) medical devices. The 2025 biennial members … Read more

Clin Chem Lab Med. 2026 Mar 13. doi: 10.1515/cclm-2026-0309. Online ahead of print. ABSTRACT Point-of-care testing (POCT) represents a breakthrough technology in laboratory medicine that has expanded rapidly over the past three decades. Today, it accounts for approximately 25 % of all laboratory tests performed worldwide. POCT was initially implemented in critical care settings due … Read more

Clin Chem Lab Med. 2026 Mar 13. doi: 10.1515/cclm-2025-1743. Online ahead of print. ABSTRACT Neurofilament light chain (NfL) has been identified as a sensitive and broadly validated biomarker of neuroaxonal injury across multiple neurological conditions, including multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), and atypical parkinsonian syndromes. This position paper provides a … Read more

Clin Chem Lab Med. 2026 Mar 13. doi: 10.1515/cclm-2026-0057. Online ahead of print. ABSTRACT OBJECTIVES: Measurement of the concentrations of vitamin D metabolites is clinically important because abnormal levels are associated with perturbations in calcium and phosphorus homeostasis. The objective of this study was to evaluate analytical performance of the Ionify® Vitamin D iPack that … Read more

Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2026-0251. Online ahead of print. ABSTRACT OBJECTIVES: Cervical lymph node metastases represent a key challenge in patients with differentiated thyroid carcinoma (DTC). Fine-needle aspiration cytology (FNAC) and thyroglobulin (Tg) measurement in fine-needle washout (FNA-Tg) are widely used but have recognized limitations. Cytokeratin 19 fragment 21-1 measurement in … Read more

Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2026-0101. Online ahead of print. ABSTRACT Clinical endocrinology relies critically on high-quality biochemical data for diagnosis, therapeutic decisions, and long-term patient monitoring. As endocrine diagnostics grow more complex due to expanding test menus, technological advances, and changing patient populations, the need for a strong, structured partnership between … Read more

Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2025-1169. Online ahead of print. ABSTRACT OBJECTIVES: Accurate measurement of 17α-hydroxyprogesterone (17-OHP) in human serum and plasma is required for steroid profiling, to ensure the appropriate diagnosis of congenital adrenal hyperplasia. Therefore, an isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) to quantify 17-OHP … Read more

Clin Chem Lab Med. 2026 Mar 12. doi: 10.1515/cclm-2026-0328. Online ahead of print. NO ABSTRACT PMID:41808360 | DOI:10.1515/cclm-2026-0328

Clin Chem Lab Med. 2026 Mar 5. doi: 10.1515/cclm-2025-1493. Online ahead of print. ABSTRACT OBJECTIVES: To determine the prevalence and clinical associations of rare HEp 2 indirect immunofluorescence ANA patterns and to evaluate their relationships with disease categories, ANA titers, and expression form. METHODS: We retrospectively analyzed 366,524 ANA tests performed between 2018 and 2024 … Read more

Clin Chem Lab Med. 2026 Mar 10. doi: 10.1515/cclm-2025-1366. Online ahead of print. ABSTRACT OBJECTIVES: The quantification of linezolid in serum and plasma matrices is crucial for therapeutic drug monitoring and pharmacokinetic studies. A reference measurement procedure (RMP) was developed and validated to provide accurate, precise, and reliable measurements, fit for its intended use while … Read more