Clinical Chemistry and Laboratory Medicine

From conventional to personalized reference intervals and decision limits: addressing latent errors in the post-post analytical phaseAbdurrahman Coskunon November 27, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 28. doi: 10.1515/cclm-2025-1338. Online ahead of print. ABSTRACT Laboratory errors are an important component of medical errors and are predominantly associated with the extra-analytical phases of the total testing process, particularly the pre-pre-analytical and post-post-analytical phases, which are largely dependent on clinical activities but also require laboratory support. The … Read more

Addressing the silent epidemic of recreational nitrous oxide use: a position, call to action and recommendations by the European Federation of Clinical Chemistry and Laboratory Medicine Committee on Biological Markers of Nitrous Oxide AbuseGuillaume Grzychon November 26, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 20. doi: 10.1515/cclm-2025-1060. Online ahead of print. ABSTRACT Recreational nitrous oxide (N2O) use has emerged as a growing public health concern, with increasing reports of neurological, psychiatric, and thrombotic complications. This position paper from the EFLM Committee on Biological Markers of Nitrous Oxide Abuse highlights the urgent need for … Read more

Performance evaluation of a new high-sensitivity cardiac troponin T assay: hs-cTnT (CLIA) assayXin Shuon November 25, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 26. doi: 10.1515/cclm-2025-1258. Online ahead of print. ABSTRACT OBJECTIVES: The Fourth Universal Definition of Myocardial Infarction recommends high-sensitivity cardiac troponin (hs-cTn) as the preferred biomarker for diagnosing myocardial infarction. This study evaluated the analytical and clinical performance of a novel hs-cTnT chemiluminescence immunoassay (CLIA) developed by Mindray. METHODS: Analytical … Read more

Implementation of an automated alert system of critical results in hospitalized and emergency patientsAngela García-de la Torreon November 21, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 24. doi: 10.1515/cclm-2025-1312. Online ahead of print. ABSTRACT OBJECTIVES: The accurate and timely identification and notification of critical results (CR) are crucial to ensure patient safety and is an integral part of the process of medical validation of laboratory results. The objective of the study was to evaluate whether … Read more

Recommendations from the IFCC Working Group on Laboratory Errors and Patient Safety for the Global Adoption of an Essential Quality Indicators Panel in Laboratory MedicineVincent De Guireon November 19, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 20. doi: 10.1515/cclm-2025-1462. Online ahead of print. ABSTRACT OBJECTIVES: To maximize participation in the international standardization effort, this recommendation aims to update the international guidance of the Working Group on Laboratory Errors and Patient Safety of the International Federation of Clinical Chemistry and Laboratory Medicine by identifying a limited … Read more

Uracil in plasma: comparison of two in-house-developed LC-MS/MS methodsSvend H Hansenon November 15, 2025 at 11:00 am

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Clin Chem Lab Med. 2025 Nov 17. doi: 10.1515/cclm-2025-0782. Online ahead of print. ABSTRACT OBJECTIVES: To prevent intoxication with 5-fluorouracil (5-FU) during chemotherapy, the initial measurement of plasma uracil levels has recently been recommended by the European Medicines Agency. Here we present and compare two new chromatographic methods for analysis of uracil in plasma. Two … Read more

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